الفهرس | Only 14 pages are availabe for public view |
Abstract Cancer refers to a massive number of diseases distinguished by the development of abnormal cells that divide uncontrollably. The diagnosis of cancer is very important and has a painful effect on patients. The changed metabolism is thought to be a cancer hallmark which has the ability to control several malignant characters to cause tumorigenesis. This work aims to use nuclear magnetic resonance as a diagnostic tool for cancer. This study included 30 plasma and 21 urine samples of patients who were diagnosed with acute lymphoblastic leukemia (ALL) + acute myeloid leukemia (AML), 25 plasma and 17 urine samples of patients diagnosed with Breast Cancer (BC) and nine plasma and urine samples obtained from healthy individuals as controls. They were prepared for NMR measurements then the metabolites were identified and the data were analyzed using multivariate statistical procedures. It is suggested that the blood plasma and urinary metabolic profiles of ALL, AML, and BC are different. They were also unlike when compared to the normal individuals. We recommend that studies on diagnosing cancer should be linked to metabolomics with the use of nuclear magnetic resonance as a rapid and non-invasive diagnostic tool. |