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العنوان
Possible Ameliorative Effect of Dihydroxyflavone on a Rat Model for Parkinson’s Disease /
المؤلف
Gaballa, Ahmed Mohamed Mohamed Abdelmaqsoud.
هيئة الاعداد
باحث / أحمد محمد محمد عبد المقصود جاب الله
مشرف / علي محمد علي عبدالعال
مشرف / حمدي حامد سويلم
مشرف / سيف الدين محمد الدولتلي
تاريخ النشر
2022.
عدد الصفحات
191p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
علم الحيوان والطب البيطري
تاريخ الإجازة
1/1/2022
مكان الإجازة
جامعة عين شمس - كلية العلوم - قسم علم الحيوان
الفهرس
Only 14 pages are availabe for public view

from 191

from 191

Abstract

I. ABSTRACT
Parkinson’s disease (PD) is a neurodegenerative movement disease that is associated with strong motor and non-motor symptoms. Current treatments mostly focus on alleviating the associated symptoms, however significant side- effects cannot be ignored. This issue motivated scientists to do more efforts to explore more of nutraceuticals such as chrysin as a potential treatment of PD. Neuroprotective effects of chrysin have been explored in multiple studies of traditional neurotoxins such as 6-hydroxy-dopamine (6-OHDA) and 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in animal models of PD. In this work, we assess the therapeutic effects of chrysin in rotenone-induced PD in rats by examining the behavioral, electrophysiological, neurochemical, biomarkers of oxidative stress, and histopathological characteristics. The present study used chrysin as an alternative to L-dopa, in addition to its use as a supplement to a low dose of L-dopa. chrysin and L-dopa were administered for 28 days after the last injection of rotenone. Our results revealed that treatment with chrysin ameliorated the rotenone-induced Parkinson-like effects. A clear amendment of the motor deficits as assessed by rotarod was observed in the chrysin-treated group compared to the rotenone group. A significant increase in dopamine (DA), norepinephrine (NE), and 5-
hydroxytryptamine (5-HT) levels was achieved as a result of chrysin treatment. Moreover, treatment with chrysin significantly reversed the rotenone-induced effects on the firing rate of striatal neurons recorded in vivo as well as their firing characteristics. Similar effects were identified in the analysis of oxidative stress, inflammatory correlates, and histopathological changes in different brain areas, where the findings showed that chrysin treatment displayed significant improvement in the neuronal architecture and decrease of damage caused by rotenone in different brain regions. This appeared in the form of moderate ameliorative efficacy. The results suggest that chrysin could represent an effective nutraceutical in treating rotenone-induced PD as achieved by its antioxidant, anti-inflammatory, and anti-apoptotic activities that lessen or prevent the aggravation of the disease.