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العنوان
The Combined Cytotoxic Effect of Cisplatin and Honey Bee Venom on Oral Squamous Cell Carcinoma Cell Line /
المؤلف
Amar, Sabreen Gamal Khalil.
هيئة الاعداد
باحث / صابرين جمال خليل عمار
مشرف / عمرو حلمي مصطفي البلك
مشرف / شريف فاروق الجيار
مشرف / مي إبراهيم علي شلقامي
الموضوع
Mouth - Cancer. Squamous cell carcinoma. Mouth - Cancer - Treatment. Squamous cell carcinoma - Treatment.
تاريخ النشر
2022.
عدد الصفحات
115 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
Dentistry (miscellaneous)
تاريخ الإجازة
1/1/2022
مكان الإجازة
جامعة المنيا - كلية طب الأسنان - باثولوجيا الفم والوجه والفكين
الفهرس
Only 14 pages are availabe for public view

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from 150

Abstract

Oral malignant growth (OC) refers to cancer created in the tongue, lips, acute sense of taste, upper and lower alveolar edges, oral mucosa, retromolar region, and floor of the mouth.
Squamous cell carcinoma (SCC) is the most widely recognized type of OC that begins in the layer of squamous epithelial cells that make up the outer layer of the head and neck.
Squamous cell carcinoma of the tongue is the most common lesion of the head and neck.
Over the past three decades, the rate of resistance for a wide range of malignant tumors has increased primarily due to successful improvement in designated treatment. In this way, there is a need to relentlessly cultivate new biologics that could work alone or in mixtures to combat complex malignant growth infections.
OSCC has been linked to risk factors such as tobacco and alcohol use. Recently, HPV has been recognized as an etiologic variable in squamous cell carcinoma of the head and neck.
Common methodologies for OC include a medical procedure, which is decision therapy, ionizing radiation, chemotherapy, or a mixture of these methodologies. It has been observed that chemotherapy offers a considerable improvement in organ preservation and decreases the rate of disease metastasis.
Cisplatin is a chemotherapy drug with perceived benefit in the treatment of various malignant tumors in humans, including diseases of the head and neck, bladder, lungs, ovaries, breasts and breasts. testicles.
Cisplatin causes apoptosis in malignant growth cells due to its ability to crosslink with purine bases on DNA, to enter the DNA binding component and to damage DNA.
In recent times, creating a safe and effective enemy of malignant growth specialists from normal sources to overcome cisplatin obstruction and unwanted side effects has been widely regarded. Apis mellifera toxin is a clear and confusing liquid of many dynamic peptides, chemicals, and amines that have an assortment of pharmacological effects on the human body.
For millennia, hornet toxin (BV) has been used in clinical applications to treat a variety of problems.BV fluctuated natural exercises, including antimicrobial, soothing and cellular strengthening against disease exercises.Estimate = 0.0001.
Our review demonstrated that established cisplatin and BV have a synergistic impact and may provide treatment for patients with malignant tongue growth.