الفهرس 
Carbon tetrachloride CCl4Only 14 pages are availabe for public view
 |  | from | 111 |  |  |
| | | from | 111 | | |
Abstract
Nanotechnology is one of the most rising up in modern science. A few years ago, natural product therapies play an important role in health care. The major application of nanotechnology in medicine was the development of nanoparticles as drug delivery system. The main advantages of using nanoparticles are large surface area, controlled particle size, site specific targeting, bioavailability, stability, biodegradable and controlled release of drug. The present study had enhanced the natural products activity with the nanotechnology model, resulting of curcumin – chitosan nanoparticles as a great chance to apply the modern nanotechnology techniques in the prevention and treatment of liver fibrosis induced by carbon tetrachloride (CCl4) in male albino mice. Where, 30g mice were divided into four groups; normal control, CCl4, prevention and treatment group. Mice were intraperitoneal (IP) injected by CCl4 three times a week for 4 weeks with dose of 0.5 ml / kg body weight to induce liver fibrosis. While, mice were orally administrated nano curcumin – chitosan mixture (100 mg : 100 mg) / 1 kg body weight 5 times a week for 4 weeks as a technique of prevention and treatment.
Several parameters were measured such liver enzymes (ALT, AST & ALP), AFP, Caspase-3, oxidative stress biomarker (MDA), antioxidant biomarkers (GSH & CAT) and histopathological study. The results showed that nano curcumin – chitosan mixture has the ability to regulate the level of liver enzymes, AFP, Caspase-3, MDA, GSH and CAT compared to CCl4 group. Histopathological samples stained with H & E, Mason’s trichrome and acridine orange stains approved the biochemical finding as a result of nano curcumin – chitosan mixture administration.