الفهرس 
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Abstract
Summary
Incidence of sepsis is likely reflecting aging populations with more co-morbidities, greater recognition, Although the true incidence is unknown, conservative estimates indicate that sepsis is a leading cause of mortality and critical illness worldwide.
The aim of our study is to evaluate the level of RDW and Lactate as markers in patients with sepsis and detect their levels on the outcome and resolution of septic shock in ICU.
RDW is a measure of the variability in the size of circulating red blood cells and is a part of the complete blood count (CBC) panel.
The serum arterial lactate concentration reflects the balance between net lactate production and net lactate consumption or clearance; Hyperlactatemia is typically present in shock states when oxygen consumption becomes critically dependent on oxygen delivery.
This study conducted on 40 patients admitted to the intensive care unit of Damanhur Medical National Institute with signs and symptoms of sepsis. Patients will be classified into two groups:
group A: Included 20 patients who have sepsis and the RDW levels were detected in those who have signs of clinical cure.
group B: Included 20 patients who have sepsis and serum Lactate levels were detected in those with signs of clinical cure.
The mechanism of increase value of red cell distribution width in these patients is unknown, but it has been suggested that the inflammatory process is associated with this increase.
The serum arterial lactate concentration reflects the balance between net lactate production and net lactate consumption or clearance, Hyperlactatemia is typically present in shock states when oxygen consumption becomes critically dependent on oxygen delivery.
In group (A) RDW at admission was ranged between 11.8-17.8 with a mean value of 141.7 while with complete cure it was ranged between 11-12.5 with a mean value of 11.45; with Statistical significant change in RDW levels at admission and at complete cure (P = 0.000).
In group (B) Lactate levels at admission was ranged between 2.1-11 with a mean value of 5.12.9 while with complete cure it was ranged between 0.5-3 with a mean value of 10.6; with statistically significant reduction in Lactate level with complete cure compared with these levels at admission in cases of sepsis (P = 0.000).
Depending on this study we can recommend RDW and lactate level as prognostic marker of sepsis and septic shock