الفهرس 
Review of LiteratureOnly 14 pages are availabe for public view
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Abstract
Neonatal jaundice is a common health problem and is expected to be seen in approximately 60%-80% of healthy newborns.
The rise of total serum bilirubin above the 95th percentile for age during the first week of life is considered as hyperbilirubinemia which occurs in nearly 8%-11% of neonates.
Hyperbilirubinemia accounts for 75% of hospitalizations occurring within the first weeks after birth. Severe hyperbilirubinemia results in irreversible neurotoxicity or kernicterus. When hyperbilirubinemia is diagnosed, the adequate treatment is required to prevent several serious complications. The exact blood level above which unconjugated bilirubin will be neurotoxic is unpredictable.
The aim of this study is to generate national parameters for neonatal jaundice and its determinants in Egypt.
Type of the study: Meta-analysis (type 3) study: We systematically searched electronic university library council data base (eulc. edu. eg) for thesis published between January 2005 and January 2015. We included only studies that controlled for the effects of confounding variables in determining maternal and infant risk factors for severe hyperbilirubinemia. We conducted meta-analysis of the eligible studies and computed the summary risk estimates with random effects models.
Birth weight in the present meta-analysis 28 studies were analyzed with total number of 2564. Total random effect (proportion % =5.75).
Formula fed in the present meta-analysis, 7 studies were analyzed with total number of cases 465. Total random (proportion is 35.67%)
APGAR score at 1 minute in the present meta-analysis, 8 studies were analyzed with total number of cases 418, Total random proportion is 16.61.
APGAR score at 5 minutes in the present meta-analysis,8 studies were analyzed with total number of cases 418.Total random proportion is 23.58.
Maternal parity in the present meta-analysis,2 studies were analyzed with total number of cases 111. Total random proportion is 6.41.
Prevalence of causes of jaundice: among 32 articles were finally included, the overall pooled prevalence of causes of jaundice among Egyptian neonates were: ABO incompatibility (proportion= 36.3%), rh-incompatibility (proportion= 16.29%), cephalhematoma (proportion= 6.52%), G6PD deficiency (proportion=4.14%), other causes (proportion= 55.3%). Jaundice treated by conventional phototherapy in the present meta-analysis with 963 cases, the proportion was 87.34%. Jaundice treated by exchange transfusion, the proportion was 16.62%.
Phototherapy is the most continent and safe therapeutic method which is used in the first step of treatment of unconjugated neonatal jaundice. It lowers the levels of serum bilirubin and decreases the need for the potentially more invasive therapeutic approach, exchange transfusion.