الفهرس 
Musculoskeletal Soft Tissue TumorsOnly 14 pages are availabe for public view
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Abstract
M
agnetic Resonance Imaging is the method of choice for the diagnostic work-up of soft tissue tumors. It is the modality of choice to evaluate such masses, because of its excellent soft tissue contrast. Although there are some findings are indicative for malignancy, such as infiltration of adjacent tissues, destruction of bones and tendons, and the size of the mass, there are no criteria available to clearly distinguish benign masses from malignancies
Diffusion-weighted magnetic resonance imaging has been mostly used for the diagnosis of suspicious, but applications in fields such as oncological and musculoskeletal imaging are being less explored. The current study enrolled 20 patients with musculoskeletal soft tissue tumors to assess the efficacy of diffusion weighted magnetic resonance imaging in characterization of musculoskeletal soft tissue tumors.
Mean of enrolled patients was 41.08 ± 11.54 year and majority (56%) of them was females. It was noticed that thigh (48%) was frequently affect in those patients followed by the arm (20%). Mean size of these masses was 100.14 ± 79.87 mm. based on histopathological evaluation of these mass; 10 (50%) masses were benign while malignant mass present in 10 (50%). Lipoma was the most frequent tumor in the current study (15%) following by haemangioma (10%).
Patients with malignant lesions had significantly lower ADC value in comparison to those with benign lesions (0.70 ± 0.09 vs. 1.58 ± 0.52 (103 mm2/s). Myxoma had the highest ADC value that was 2.44 (103mm2/s) while sarcoma had lowest value that was 0.54 ± 0.03 (103mm2/s).
It was noticed that MRI had 100% sensitivity and 90% specificity for diagnosis of malignant musculoskeletal soft tissue masses with overall accuracy was 92% and area under curve was 0.91 at cut off value was < 1.14 (103mm2/s). Based on final diagnosis; MRI was successful in diagnosis of all cases with malignant musculoskeletal soft tissue masses but as the same time, MRI falsely diagnosed two cases with benign nature to be malignant. Those two cases were finally diagnosed to be lipoma.
Based on the current study, DWI-MRI considered the method of choice for the characterization of musculoskeletal STTs; however, DW-MRI with ADC mapping is a rapidly, valuable, non-invasive, non-contrast tool for reliably differentiating between benign and malignant STTs. It’s recommended to perform such study in large sample of patients and in more centers to confirm the great values of DWI-MRI in evaluation of such lesions.