الفهرس 
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Abstract
Thyroid associated ophthalmopathy (TAO) is an auto-immune orbitopathy, associated with thyroid dysfunction. It results in compression of the orbital contents, impairment of the blood flow and thus affects the choroidal and retinal microstructure and function.
The purpose of this study is to measure the central CT in active and inactive TAO using Optical Coherence Tomography (OCT) and compare it to the control group.
The cross section study was conducted on participants from the ophthalmology clinic of the National Institute of Diabetes and Endocrinology (NIDE). The study included 160 eyes from 80 participants (40 hyperthyroidism patients and 40 control subjects). Data were collected during the period from December 2019 to June 2020.
The inclusion criteria included patients with hyperthyroidism who suffered from TAO. Both sexes were included with their ages ranging from 20 to 50 years.
Patients with unclear media, inflammatory orbital disease other than TAO, history of orbital radiotherapy, refractive error greater than 6 diopters, systemic diseases affecting the CT other than TAO (e.g. diabetes mellitus and hypertension), or ocular diseases affecting the CT (e.g. glaucoma, uveitis, retinal and choroidal diseases) were excluded from our study. Smokers and pregnant females were also rolled out during patients’ selection.
A complete ophthalmological examination was done to all participants, including, refraction, best corrected visual acuity, Anterior and posterior segment examination (using slit lamp fundoscopy), intraocular pressure measurement and ocular motility assessment.
All participants’ eyes were photographed, non- dilated, using Spectral Domain Optical Coherence Tomography (SD-OCT) (NIDEK RS-3000 advance) to measure Macula Map and sub foveal CT by Macula Line and Macula Radial.
There was no significant difference regarding age, sex, VA and IOP between TAO patients (either active or inactive) and normal subjects.
This study showed that there was a significant increase in sub-foveal CT in patients with TAO compared to the control group. It also showed a significant increase in sub-foveal CT in the active subgroup more than the inactive subgroup.
In addition, a decrease in Central subfield thickness was found in patients with TAO compared to the control group, but there was no significant difference found between active and inactive subgroups.