الفهرس 
HASHIMOTO’S DISEASEOnly 14 pages are availabe for public view
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Abstract
H
ashimoto thyroiditis (HT) is the most common autoimmune disease worldwide, characterized by chronic inflammation and circulating autoantibodies against thyroid peroxidase and thyroglobulin. Patients require hormone replacement with oral levothyroxine, and if untreated, they can develop serious adverse health effects and ultimately death. There is a lot of evidence that the intestinal dysbiosis, bacterial overgrowth, and increased intestinal permeability favor the HT development, and a thyroid–gut axis has been proposed, which seems to impact our entire metabolism.
The aim of this study was to evaluate the correlation of stool lactobacillus acidophilus and leaky gut syndrome in patients with hashimoto thyroiditis.
This was a case control study that was conducted on 60 Egyptian subjects that was divided into 2 groups, group 1 that included 30 patients with Hashimoto s thyroiditis first diagnosed or on therapy and group 2 that included 30 healthy subjects as a control, it was conducted at Ain Shams University hospital outpatient Endocrinology Clinic throughout 6 months.
All patients were subjected to: Detailed history, full clinical examination ,thyroid antibodies (Anti-TPO), thyroid profile (TSH, FT4, FT3), PCR for lactobacillus acidophilus in stool and zonulin level in serum (marker for leaky gut).
RESULTS:
Hashimoto thyroiditis patient group and control group were matched regarding Age and Gender.
There was high significant statistical difference found between Hashimoto thyroiditis group and control group regarding FT4 being higher in the control group and TSH being higher in the patient group. (P-Value <0.001). However ,There was no significant statistical difference found between two groups regarding FT3. (P- value >0.05)
There was high significant statistical difference found between two Hashimoto thyroiditis patient group and control group regarding Anti tpo, being higher in the Hashimoto thyroiditis group. (P-Value <0.001).
There was high significant statistical difference found between two Hashimoto thyroiditis patient group and control group regarding zonulin level, being higher in the Hashimoto thyroiditis group. (P-Value <0.001).
There was high significant statistical difference found between two Hashimoto thyroiditis patient group and control group regarding Lactobacillus PCR, being higher in the Hashimoto thyroiditis group. (P-Value <0.001).
Hashimoto thyroiditis Patients group was divided into newly diagnosed and on treatment and there was no statistical significant difference between them regarding the demographic data , Anti TPO, Zonulin and lactobacillus PCR .(P-Value > 0.05).
In the Hashimoto thyroiditis patients group there was significant statistical difference between positive and negative lactobacilius group regarding TSH and zonulin being significant in the positive lactobacilius group (P-Value < 0.05)
Also In the Hashimoto thyroiditis patients group there is high significant statistical relation between the two groups regarding anti-TPO being higher in the positive lactobacilius group (P-Value <0.001).
Also in the Hashimoto thyroiditis patients group there is positive correlation between zonulin level, anti tpo and TSH and high significant statistical relation between zonulin and lactobacilius.
Our study showed statistically significant increase in serum zonulin level in hashimoto thyroiditis patients implicating a possible presence of leaky gut syndrome and associated with lactobacillus PCR positivity which reflect a bacterial dysbiosis .This data may reflect the interaction between the gut microbiota and possible leaky gut syndrome and an association with Hashimoto thyroiditis.However ,wether this data is a result from hashimoto or a cause ,this will need a further evaluation.
CONCLUSION
O
ur study showed statistically significant increase in serum zonulin level in hashimoto thyroiditis patients implicating a possible presence of leaky gut syndrome and associated with lactobacillus PCR positivity which reflect a bacterial dysbiosis .This data may reflect the interaction between the gut microbiota and possible leaky gut syndrome and an association with Hashimoto thyroiditis.However ,whether this data is a result from hashimoto or a cause ,this will need a further evaluation.
RECOMMENDATION
F
Urther studies are needed on gut microbiota by sequencing technique for additional knowledge regarding the change of gut microbiota and the possible link with leaky gut and hashimoto thyroiditis.