الفهرس 
Aim of the WorkOnly 14 pages are availabe for public view
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Abstract
Summary
IBS is one of the most common Functional Gastrointestinal disorder (FGID) and diseases of brain–gut interaction, characterized by change in bowel habits accompanied by recurrent abdominal pain, bloating, and disordered defecation in the absence of any underlying pathology of the gastrointestinal tract.
The main hypothesis of IBS pathology implies an immune activation probably involved in a sort of low-grade inflammation and increased mucosal permeability that activates local reflex mechanisms, stimulating secretion and sensory pathways that lead to increased visceral sensation.
Diet and dietary antigens play a huge role in the generation of IBS symptoms. Dietary manipulation (low FODMOP diet) was proposed to reduce IBS symptoms. As any elimination diet, it may be associated with nutritional and micronutrients deficiency such as vitamin D and zinc.
Zinc is an essential trace element plays a key role in the development and maintenance of all tissues. Several studies showed that low Zn consumption and deficiency may lead to the damage of intestinal mucosa. Also, the anti-inflammatory functions of Zn may reduce celiac disease symptoms, as well as other chronic GI disorders such as IBS and Crohn’s disease.
The present work aimed to measure the proportion of IBS and its subtypes in medical students participated in NAMES/ASU project and to correlate dietary intake and serum level of Zn with IBS.
This cross-sectional study of purposive sample involved 199 medical students (males and females) participated in NAMES/ASU project, their ages ranged from 17 to 26 years old who had GIT symptoms for at least, the past 6 months.
For clinical diagnosis of IBS, Rome IV criteria was used. It showed the proportion of IBS among the studied student about 8.5% (104 students) and the IBS-C subtype was the most common type followed by IBS-D.
In descriptive analysis of IBS students’ group, there was a female predominance about 81(77.9%) against 23(22.1%) for male students. Also, most of IBS students were in the senior academic year (4th, 5th, and 6th school years).
Regarding the anthropometric measurements, there were no significant difference between the IBS and Non-IBS students except for waist/hip ratio that was higher in non-IBS female students.
Results of General clinical examination, which included skin, nail, hair, and lips that might be related to zinc deficiency, showed no statistically significant difference between the two groups except for pale nails and rough skin were more recorded in IBS students.
On statistical analysis of GIT symptoms, (abdominal pain, diarrhea, and constipation), showed a highly significant difference between the two studied groups, in which abdominal pain and constipation were recorded more in IBS students, while diarrhea was more pronounced in non-IBS students.
IBS is one of the most common Functional Gastrointestinal disorder (FGID) and diseases of brain–gut interaction, characterized by change in bowel habits accompanied by recurrent abdominal pain, bloating, and disordered defecation in the absence of any underlying pathology of the gastrointestinal tract.
The main hypothesis of IBS pathology implies an immune activation probably involved in a sort of low-grade inflammation and increased mucosal permeability that activates local reflex mechanisms, stimulating secretion and sensory pathways that lead to increased visceral sensation.
Diet and dietary antigens play a huge role in the generation of IBS symptoms. Dietary manipulation (low FODMOP diet) was proposed to reduce IBS symptoms. As any elimination diet, it may be associated with nutritional and micronutrients deficiency such as vitamin D and zinc.
Zinc is an essential trace element plays a key role in the development and maintenance of all tissues. Several studies showed that low Zn consumption and deficiency may lead to the damage of intestinal mucosa. Also, the anti-inflammatory functions of Zn may reduce celiac disease symptoms, as well as other chronic GI disorders such as IBS and Crohn’s disease.
The present work aimed to measure the proportion of IBS and its subtypes in medical students participated in NAMES/ASU project and to correlate dietary intake and serum level of Zn with IBS.
Summary
85
This cross-sectional study of purposive sample involved 199 medical students (males and females) participated in NAMES/ASU project, their ages ranged from 17 to 26 years old who had GIT symptoms for at least, the past 6 months.
For clinical diagnosis of IBS, Rome IV criteria was used. It showed the proportion of IBS among the studied student about 8.5% (104 students) and the IBS-C subtype was the most common type followed by IBS-D.
In descriptive analysis of IBS students’ group, there was a female predominance about 81(77.9%) against 23(22.1%) for male students. Also, most of IBS students were in the senior academic year (4th, 5th, and 6th school years).
Regarding the anthropometric measurements, there were no significant difference between the IBS and Non-IBS students except for waist/hip ratio that was higher in non-IBS female students.
Results of General clinical examination, which included skin, nail, hair, and lips that might be related to zinc deficiency, showed no statistically significant difference between the two groups except for pale nails and rough skin were more recorded in IBS students.
On statistical analysis of GIT symptoms, (abdominal pain, diarrhea, and constipation), showed a highly significant difference between the two studied groups, in which abdominal pain and constipation were recorded more in IBS students, while diarrhea was more pronounced in non-IBS students.