الفهرس | Only 14 pages are availabe for public view |
Abstract Summary This case-controlled study aimed to assess serum and semen level of Galactin-1 in azoospermic patients. Overall, 100 men were allocated into:- Fertile normozoospermic men (n=50). Infertile azoospermic men(n=50). Inclusion criteria: obstructive or non-obstructive azoospermic men with normal karyotyping. Exclusion criteria: abnormal karyotyping, varicocele, leukocytospermia , smoker and drug addicts . They were subjected to : 1-History taking . 2- General and clinical examination . 3-Semen analysis according to WHO guidelines(2010). 4-estimation of serum and semen galactin-1 by R&D Systems (bio-techne) kits ,minneopolis , USA & Canada). The results were as follows: 1-The mean seminal plasma galactin-1 was higher in cases than in controls and there was statistical difference found. 2-The mean of galactin-1 in serum showed no statistical difference between cases and controls. 3-There was a statistical negative correlation between Johnson’s score and the level of galactin-1 in semen 4-There was non- significant positive correlation between jonson’s score and the level of galactin-1in serum. 5- There was non-significant negative correlation between age and galactin-1 in serum and semen. Conclusion it can be concluded from this study that increased seminal Gal-1 is associated with azospermia and it’s correlation with the severity of azoospermia according to jonson’s score. Recommendations Further studies of semen and serum galactin-1 are needed to determine its relation to azoospermia on larger samples and long follow up period . |