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العنوان
Clinical Utility of Lymphocytes Apoptosis Related Proteins in Assessment of Hepatic Fibrosis in HCV Infected Patients /
الناشر
Aml Mamoud Hassan Alsharkawy,
المؤلف
Aml Mamoud Hassan Alsharkawy.
هيئة الاعداد
باحث / Aml Mahmoud Hassan AlSharkawy
مشرف / Elshahat Abou Mosalam Toson
مشرف / Gamal Elsayed Shiha
الموضوع
HCV. Immunity. Lymphocytes Apoptosis.
تاريخ النشر
2020.
عدد الصفحات
145 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
Chemistry (miscellaneous)
الناشر
Aml Mamoud Hassan Alsharkawy,
تاريخ الإجازة
1/10/2021
مكان الإجازة
جامعة دمياط - كلية العلوم - الكيمياء
الفهرس
Only 14 pages are availabe for public view

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from 166

Abstract

Hepatitis C virus (HCV) is a significant public health problem. Liver fibrosis is a common endpoint of clinical trials in chronic hepatitis C (CHC). The assessment of fibrosis provides much information Currently, liver biopsy is considered the gold standard for the detection of fibrosis. However, after biopsy 30% of patients feels pain, These limitations have led to development of noninvasive methodologies for the assessment of fibrosis. Ideally, noninvasive alternatives should be simple, cheap, and easy to perform, safe, precise, reproducible, and capable of differentiating patients in need of therapy. The cell’s death is choreographed by a set of previously dormant proteases, the caspases, which cleave several hundred cellular substrates. Two principal pathways to caspase activation have been recognized. One is the death receptor pathway (extrinsic pathway), The second apoptosis pathway (intrinsic pathway) is induced by mitochondria in response to DNA damage, oxidative stress, and viral proteins . Herein, we aimed to determine T lymphocyte subpopulation peripheral CD4+ and CD8+ and then estimating their performances as surrogate markers for liver fibrosis diagnosis. In addition to assessment of apoptosis status in that cells. Furthermore, we aimed to derive a sensitive function incorporated CD4+/CD8+ ratio with other indirect markers which reflect alteration in hepatic function for liver fibrosis staging in CHC patients and then compared its performance with some published noninvasive tests in CHC patientsز Our data confirm previous findings that HCV infection is associated with upregulation of the extrinsic apoptosis pathway. Furthermore, peripheral T cell apoptosis was associated the stage of liver fibrosis, suggesting that T cell apoptosis in the peripheral level play a prominent role in liver fibrosis.