الفهرس 
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Abstract
Background: The application of mechanical ventilation for critically ill patients is a life-support system that can maintain their adequate lung function. Positive end-expiratory pressure is a significant adjunct mode for mechanically ventilated patients. Traditionally, there is relationship between elevation of Positive end-expiratory pressure on central venous pressure and hemodynamic state. It is ordinarily applied for mechanically ventilated patients to improve oxygenation, alveolar ventilation, reduce atelectasis and ventilation/perfusion mismatch. Although several international studies revealed the extensive positive effects of high positive end-expiratory pressure (≥ 10 cmH2O) for critically ill patients with or without lung disorders, low levels of positive end-expiratory pressure (3 to 5 cmH2O) are regularly used for mechanically ventilated patients. Aim: The current study aimed to investigate the impact of different values of positive end-expiratory pressure on central venous pressure reading among critically ill patients. Method: A quasi-experimental research design was utilized in the current study involving a convenience sample of 164 adult mechanically ventilated patients. Data were collected using a critically ill patient’s ventilation, oxygenation and hemodynamics parameters assessment tool. Results: The current study revealed that the modification of positive end-expiratory pressure values from moderate (6-8 cmH2O) to high (8-10 cmH2O) improved patients’ central venous pressure reading, hemodynamic state, oxygenation and ventilatory parameters. Conclusion and recommendations: elevation of positive end-expiratory pressure (6-10) can improve mechanically ventilated patients’ ventilation, CVP and hemodynamic parameters. More investigations are required to support the evidence of using this approach when caring for mechanically ventilated patients.