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العنوان
The comparison of procalcitonin guidance in administration of antibiotic with empirical antibiotic therapy in critically ill patients with SIRS admitted in intensive care unit \
المؤلف
El Ghazaly, Ahmed Eid.
هيئة الاعداد
باحث / أحمد عيد الغزالي
مشرف / بهاءالدين عويس حسن
مشرف / أحمد نجاح الشاعر
مشرف / رانيا مجدي علي
تاريخ النشر
2021.
عدد الصفحات
71 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
العناية المركزة والطب العناية المركزة
تاريخ الإجازة
1/1/2021
مكان الإجازة
جامعة عين شمس - كلية الطب - الرعاية المركزة العامة
الفهرس
Only 14 pages are availabe for public view

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Abstract

Objective: to assess the clinical value of daily serum PCT measurements for guiding the initiation of antibiotic treatment in intensive care patients with SIRS without evident infection and compare it with empiric antibiotic administration on admission.
Patients and Methods: This randomized double blinded prospective controlled clinical study was conducted on 72 patients with SIRS without evident sepsis admitted to the intensive care unit of the obstetrics and gynecology hospital in Ain Shams University Hospitals from October 2018 to December 2020.
Results: Procalcitonin level was elevated above the cut off value of 2 ng/ml in 15 patients in the PCT-guided antibiotic therapy group and 11 patients in the empiric antibiotic therapy group. Procalcitonin elevation above 2 ng/ml in the surgical subset was more significant than in the medical subset in both groups. The SOFA score and the length of ICU stay were not statistically significant different between the two groups.
Conclusions: Postponing antibiotic therapy in patients admitted to ICU with suspected noninfectious SIRS until PCT is higher than 2 ng/ml is safe especially in medical ICU.