الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Nanotechnology has proved its significant effect in drug delivery, recently. In this study, a good use of nanotechnology was made. Five drugs were synthesized in lab in order to remedy diabetes of type 1 and type 2 and to decrease the consequent diabetic inflammation. All of them were of a particle size within the nano-range. The drugs are Zinc oxide nanoparticles (ZnONPs), Zinc Oxide-Insulin nanoparticles (ZnONPs-Insulin) of ratio 1:1, Zinc oxide-Insulin nanoparticles of ratio 1:0.5, Zinc oxide-Insulin nanoparticles of ratio 1:0.25, Zinc oxide-Curcumin nanoparticles (ZnONPS-CurcuminNPs) of ratio 1:10,-3 Zinc oxide-Curcumin nanoparticles (ZnONPS-CurcuminNPs) of ratio 1:10-4 and Zinc oxide-Curcumin nanoparticles of ratio 1:10-5 . The nanomeric drugs were characterized using XRD, HRTEM, FTIR, EDX and surface area to prove a successful adsorption of the reacting particles and identify the shape and size of the reacting particle. A biological experiment was performed using Albino rats to assess the hypoglycemic effect of five prepared drugs plus Curcumin in the nanorange and comparing it with that of Insulin. An oral glucose tolerance test (OGTT) was performed to the experimental rats on the last day of the experiment in order to check the hypoglycemic effect of the prepared drugs with time. Also, blood samples were withdrawn from the experimental rats for performing glycated hemoglobin (HBA1C) analysis. The whole biochemical analysis revealed the effect of the prepared drug samples and the most potent hypoglycemic drug was found to be ZnONPs-Insulin with the ratio 1:1. After sacrificing of experimental animals, their liver and pancreas specimens were taken to be examined for histopathology. It was found that ZnONPs and ZnONPs-CurcuminNPs has the best effect on pancreas and liver specimens.