الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Ehrlich solid tumor (EST), derived from the mouse breast adenocarcinoma which is an aggressive and fast growing carcinoma able to develop both in the ascetic or in the solid form depending whether inoculated intraperitoneal or subcutaneous, respectively. The current study aims to evaluate the protective effect of spirulina nanoparticles (SP NPs) against Ehrlich solid tumor induced breast cancer, alterations in tumor structure, alpha fetoproteins, DNA fragmentation and P53 and Bcl2 proteins expression in tumor. A total of 80 female mice were randomly assigned into five groups (1st, Control; 2nd, SP NPs; 3rd, EST; 4th, EST +SP NPs). Results revealed increased incidences of tumor growth in the untreated EST group, along with elevated levels of serum AFP, CEA, serum ALT, AST, ALP, urea, creatinine, K+, C1+, and DNA damage. Treatment of EST with SP NPs (EST+ SP NPs) modulates and improved these changes in liver and kidney functions, enzymatic and non-enzymatic oxidative stress, tumor markers and DNA damage as compared to mice bearing EST, in addition to a significant increase in, P53, and decrease in Bcl2 proteins expressions in tumor sections. However, treatment of EST bearing mice with SP NPs normalized serum levels of the above-mentioned parameters, inhibit the tumor development and reduced DNA damage and P53 proteins expressions. These results suggest that SP NPs may have hepatic and renal protective, antioxidant, anti-cancer and anti-apoptosis properties; in addition to inhibition of the EST development, and DNA damage induced by EST.