الفهرس 
Literature ReviewOnly 14 pages are availabe for public view
 |  | from | 124 |  |  |
| | | from | 124 | | |
Abstract
The present study was concerned with evaluating the value of adding L-Arginine to
Sildenafil and study its effect on improving erectile function and test its tolerability and
efficacy in patients having organic non psychogenic erectile dysfunction. Out of a total of 85
patients screened; only seventy patients fulfilled the inclusion criteria and were enrolled into
the study. The seventy patients were randomly assigned into two arms of the study. Eleven
patients were excluded from the study due to failure to adhere to the required office visits. The
current study included (59) patients; (29) patients in the Sildenafil (S) group & (30) patients in
the combination group (AS)
The sociodemographic data was comparable between the two groups. Associated
morbidities as diabetes, hypertension and smoking were comparable between the two groups
as the majority of cases had neither Diabetes Mellitus nor Hypertension. All the cases were
married with positive sexual history. The mean age was 56.3±5.1 years and 56.2±4.4 years in
Sildenafil and combination groups respectively.
At baseline the results of both clinical penile rigidity and the score of international index
of erectile function (IIEF) showed a non-significant difference between the two groups;
whereas there was statistically significant difference in the grades of erectile dysfunction in the
combination group versus Sildenafil group (p value < 0.0001).
At the end of the study evaluation of clinical penile rigidity showed statistically
significant improvement towards the combination group versus Sildenafil group (p value <
0.0001). There was a trend towards increase in the international index of erectile function score
in favor of the combination group versus the Sildenafil group but did not reach the statistical
significance.
The grades of erectile dysfunction based on the international index of erectile function
(IIEF) were statistically significant in the combination group versus the Sildenafil group.
Side effects were the same between the two groups except for gastritis which was
statistically significant among the combination group versus the Sildenafil group.
Side effects were mild with no patients needing to withdraw from the study or to
discontinue medication.
In conclusion, suggests the beneficial role of adding L-Arginine to Sildenafil in patients
with erectile dysfunction especially arteriogenic.
This combination is well tolerated and helps improve erectile dysfunction.