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العنوان
Effect of Coenzyme Q10 on
Markers of Endothelial
Dysfunction in Pediatric
Patients with Type 1 Diabetes
Mellitus /
المؤلف
Serag, Heba Ibrahim Mohamed.
هيئة الاعداد
باحث / هبه ابراهيم محمد سراج
مشرف / لمياء محمد الوكيل
مشرف / اميرة عبد المنعم عدلى
مناقش / اميرة عبد المنعم عدلى
تاريخ النشر
2021.
عدد الصفحات
190 P. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
العلوم الصيدلية
تاريخ الإجازة
1/1/2021
مكان الإجازة
جامعة عين شمس - كلية الصيدلة - قسم الصيدلة الاكلينيكية
الفهرس
Only 14 pages are availabe for public view

from 190

from 190

Abstract

Type 1 diabetes mellitus (T1DM) is one of the most common endocrine disorders that occur during childhood. It accounts for about 10 % of all diabetic cases. It is defined as an autoimmune disease characterized by the destruction of the insulin-producing β-cells of the pancreas.
Patients with T1DM are subjected to the incidence of vascular complications that start early from childhood and were found to be the main cause of morbidity and mortality among these population. where the earliest feature of those vascular complications is endothelial dysfunction.
Endothelial dysfunction (ED) is defined as a defect in the ability of the endothelium to maintain vascular homeostasis. It reflects a reduction in bioavailable nitric oxide, increased synthesis of vasoconstrictors and disturbed regulation of thrombosis, inflammation and cell growth of vascular wall. Therefore, endothelial function is considered an outstanding indicator for vascular health and an important target to gauge cardiovascular risk.
Adhesion molecules are important markers of ED. They play a vital role in the pathogenesis of cardiovascular disease and have been associated with the development of vascular complication of diabetes in some studies.
Coenzyme Q10 (CoQ10) is a vitamin like compound, synthesized in the body and obtained from food. It functions as an anti-inflammatory and antioxidant, and an essential intermediate in the electron transport chain and production of ATP.
Serum CoQ10 concentration was found to be reduced in diabetic patients suggesting the presence of high oxidative stress state in those patients. Moreover, CoQ10 supplementation has yielded promising results on endothelial dysfunction and metabolic parameters in a number of clinical studies. That gave a rise for a question about the beneficial effect of CoQ10 supplementation among patients with T1DM.
The aim of the current study was to evaluate the impact of CoQ10 supplementation on endothelial dysfunction and metabolic parameters in pediatric patients with T1DM.
This study was a prospective, randomized, controlled, open-label study carried out on T1DM pediatric patients at the Pediatric Diabetes Clinic, Children’s Hospital, Ain Shams University, Cairo, Egypt from December 2016 to August 2018.
A total of 40 patients completed the study and they were randomly assigned to either group I (n=21); received 100 mg of CoQ10 capsules once daily in addition to standard treatment (insulin) for 3 months, or group II (n=19); received standard treatment (insulin) only for 3 months. An age and sex matched healthy control group with the same exclusion criteria (n= 7) was included for laboratory assessment only. All patients were assessed for soluble intercellular adhesion molecule (sICAM-1), glycated hemoglobin (HbA1c), fasting blood glucose (FBG), lipid profile, serum creatinine, alanine transaminase (ALT), aspartate transaminase (AST) and quality of life using pediatric quality of life inventory (PedsQL™) version 4.0 generic core scales at baseline and after 3 months of treatment.
The current study showed that:
• At baseline, sICAM-1 levels were significantly higher in group II than healthy control group (p = 0.042)
• There was no significant difference observed in sICAM-1, HbA1c, FBG, lipid profile, serum creatinine, AST, ALT or PedsQL™ 4.0 score between the two study groups after 3 months of treatment.
• There was a significant positive weak correlation between sICAM-1 and HbA1c throughout the study period (r = 0.308, p = 0.005).
Conclusion:
Supplementation with 100 mg of CoQ10 for 3 months in T1DM pediatric patients was safe and well tolerated but had no favorable effect on ED or metabolic parameters.
Recommendation:
Conduction of further larger studies for a longer duration using different CoQ10 doses to explore the potential beneficial or hazardous effects of CoQ10 in this population.