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العنوان
Evaluation of Serum Omentin-1 Levels in chronic Kidney Disease Patients with and without Type 2 Diabetes Mellitus \
المؤلف
Naguib, Tahani Abdulsalam.
هيئة الاعداد
باحث / تهانى عبد السلام نـجيب
مشرف / مـاجـدة شــكـري محمد
مشرف / رانيـا سيد عبد الباقى
مشرف / حنـــان محمــود علــى
تاريخ النشر
2020.
عدد الصفحات
150 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الطب الباطني
تاريخ الإجازة
1/1/2020
مكان الإجازة
جامعة عين شمس - كلية الطب - الباطنة العامة
الفهرس
Only 14 pages are availabe for public view

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from 150

Abstract

Background:
Omentin-1 a new anti-inflammatory adipokine has been identified as a major visceral (omental) secretory adipokine which plays important roles in glucose homeostasis, lipid metabolism, insulin resistance and diabetes.
Objectives: This study aimed to investigate the level of Omentin-1 in chronic kidney disease patients with and without type 2 diabetes mellitus.
Methods: The study included 70 patients who further subdivided into three subgroups (20 T2DM, 25T2DM+CKD, 25CKD) and 20 healthy subjects formed the control group. They subjected to full clinical examination, weight, height, waist and hip circumference and BMI was calculated.Lipid profile, omentin-1, kidney function test, UACR, and HbA1c were measured.
Results : Serum omentin-1 level was lower in all patient groups compared to healthy control. It’s level was lower in groups with T2DM than CKD only group. It had a negative correlation with HbA1c, cholesterol total, TGs, LDL-c and e-GFR ,and a positive correlation with s.creatinine, UACR, BUN, HDL-c. The best cut off point of serum omentin-1 was <=330 ng/ml to differentiate group 3(T2DM+CKD) from control group using ROC curve analysis.
Conclusion: The results of the present study suggest that diabetes mellitus may be associated with lower omentin levels in CKD population . 2