الفهرس 
AbortionOnly 14 pages are availabe for public view
 |  | from | 174 |  |  |
| | | from | 174 | | |
Abstract
Abortion is the termination of pregnancy by any
means (surgical or medical) before the age of viability.The
definition varies in duration of gestational age according to
the countries and available facilities (Chayachinda et al.,
).
Estrogen is important in the maintenance of
pregnancy. Aromatase inhibitors such as letrozole, suppress
the peripheral conversion of androgen to estrogen, the use
of letrozole combined with vaginal misoprostol was more
effective than misoprostol alone in termination of
pregnancy (Yeung et al., ).
The present study is aimed to assess letrozole as a
new synergistic agent in combination with vaginal
misoprostol compared with misoprostol alone for medical
abortion
This clinical trial was conducted at Ain Shams
University Maternity hospital in the period between
December and May .
Patients that fulfilling the inclusion criteria were
recruited, then informed written consent was taken from every patient before starting the examination That was
followed by detailed history and examination of all patients
to confirm fulfilling the inclusion and exclusion criteria.
Hemoglobin, blood group, RH and liver and kidney
function test were done for all patients before the study.
After that patients were divided into two groups;
) group A (Intervention group): women received oral
letrozole mg (four tablets mg) once daily for
days followed by single dose of mcg vaginal
misoprostol.
) group B (controlled group): women received
tablets of the placebo drug once daily for days
followed by single dose of mcg vaginal
misoprostol.
Vital data as temperature, pulse and blood pressure
were recorded every hours, side effects as abdominal
pain, fever, rigors, nausea, vomiting, headache were also
recorded.
Pelvic examination were done every two hours to
asses opening of the internal OS and to record time of
complete abortion Vaginal sonography was done after hour to confirm
whether the abortion is complete or not and the extent of
need for curettage and evacuation.
This study demonstrated that mg letrozole for three
days followed by mcg of vaginal misoprostol is more
effective than misoprostol alone for second trimester
abortion.
In the total of women were recruited the complete
abortion rate of the letrozole group was significantly higher
than that of the control group ( in the letrozole group
compared with in the control group).
No significant differences were found between the
study groups regarding demographic characteristics.
Induction of abortion to opening of internal os time
was significantly shorter among letrozole group than
among control group.
Time between induction of abortion and beginning
of expulsion of pregnancy products was significantly
shorter among Letrozole group than among control group.Induction of abortion to complete abortion time was
significantly shorter among Letrozole group than among
control group.
There were no significant differences between the
study groups regarding side effects. Severity of vaginal
bleeding was not significantly different in the letrozole
group than the control group.