الفهرس 
Type 1 Diabetes MellitusOnly 14 pages are availabe for public view
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Abstract
T1DM is one of the most common chronic diseases diagnosed in childhood (Patterson, et al., 2009). It is a chronic disorder with well-known short and long term consequences. One of the long−term consequences is severe impairment of growth and development, (Daneman, et al., 2006).
In this study we aimed to evaluate the effect of glycemic control on IGFBP-3 and growth in a sample of prepubertal Egyptian children with T1DM.
Our cross sectional study, was conducted on 80 prepubertal Egyptian children, aged 12 or less, during the period from July 2018 to August 2019. 50 of the subjects had T1DM, the subjects were recruited from the outpatient clinic of the pediatric department of Ain shams university hospitals and Pediatric outpatient clinic of National Institute of Diabetes and Endocrinology, they were classified into three groups (group I, II and III ).
All participants were subjected to full medical history taking, including a 1 day recall nutritional questionnaire, general clinical examination including anthropometric measurements (weight and height) and laboratory investigations including (Hb, s. creatinine, AST, ALT, fT4 and TSH, FBS, 2 hours PP, HbA1c, s. IGFBP-3).
Subjects with other chronic systemic diseases such as chronic liver diseases, chronic kidney diseases, thyroid disturbances, pituitary disease, as well as children less than 3 SD of mean height for age were excluded from the study.
Our results showed statistically significant reduction in height,height percentile and weight percentile in T1DM male and female patients compared tocontrolswith a meanheight in group I (129.287±13.410),group II (127.727 ±10.155)compared to (136.760±13.431) in control group III (P=0.009).
Results also showeda highly significant difference between the studied groups as regards the height percentile (P <0.001), where it was found to be highest in group III with a median (IQR) of87.07 (20.48) followed by group II at 17.93 (29.20) and then group I at14.54 (27.95). also there was a highly significant difference between the weight percentile in the studied groups (P<0.001). the weight percentile was found to be highest in group III with a median (IQR) of 85.18 (20.17) followed by group I at 40.68 (41.83) and then lastly group II at 30.64 (35.59).
A highly significant difference (P<0.001) between the three groups as regards the S.IGFBP-3 levels where the level in group III (285.333±61.936) was higher than both group I (198.6±45.335) and group II (168.4±44.317). statistically significantly lower in patients compared to controls.
Some other laboratory markers such as HbA1c, FBS and 2 hour PP blood sugar also showed highly significant difference between the three studied groups where they were higher in the patients when compared to the healthy controls.
Correlation study showed a statistically significantly positive correlation of IGFBP-3, with height, height percentile, weight percentile, skin fold thickness, mid arm circumferenceand negatively with HbA1c with p-values (<0.05).
On correlating the different anthropometric, demographic and laboratory data of the three tested groups with HbA1c, the results showed a significant difference with height with a P-value of 0.049 anda height percentile % with a P-value of 0.012, but no correlation with weight percentile.
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