الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 67 |  |  |
| | | from | 67 | | |
Abstract
Background: Regulatory T cells have an immunosuppressive function on T cell activation. They are involved in pathophysiology and treatment of immune thrombocytopenia (ITP). Circulating myeloid–derived suppressor cells (cMDSCs) are involved in immune dysregulation in ITP. Study objective was to determine the mean level of MDSCs in acute, persistent and chronic ITP, and its impact on treatment modalities and prognosis. Patients and Methods: Forty-one patients with ITP were recruited from Pediatric hematology clinic, Ain Shams University. They were classified into acute, persistent and chronic. they were compared to 20 age and gender matched as healthy controls. All patients were subjected to history taking with emphasis on age of presentation, disease duration and treatment modalities, thorough clinical examination. Mean values of CRP, ALT, S. Creatinine were collected from patients’ files. All study participants have performed CBC (Coulter), MDSCs by flow cytometry. Secondary thrombocytopenia was excluded. Results: Acute ITP was detected in 29%, 24% had persistent and 46% had chronic ITP. Their age ranged from 1- 16 years at study entry, 51.2% were male. Active disease was found in 58.5% while 41.4% in remission. No treatment was offered to 53% while 24% of patients were on steroids. MDSCs decreased significantly in ITP patients Vs control group (P < 0.001) while didn’t show significant difference among patients’ group regarding MDSCs level as P value =0.325 or with different treatment modalities. Conclusion: Reduced numbers of MDSCs play a role in pathogenesis of ITP. Yet, MDSCs didn’t differ according to disease duration or treatment modalities.