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العنوان
Soluble MICA versus Troponin as Early and Specific Predictor for Acute Myocardial Infarction in Patients with chronic Kidney Disease /
المؤلف
El-Shaer, Ahmed Ibrahim Ibrahim.
هيئة الاعداد
باحث / أحمد إبراهيم إبراهيم الشاعر
مشرف / عمرومحمد السعيد كامل
مشرف / رانيا مجدى محمد
مشرف / رانيا حسن عبد الحفيظ
تاريخ النشر
2020.
عدد الصفحات
80 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
العناية المركزة والطب العناية المركزة
تاريخ الإجازة
1/4/2020
مكان الإجازة
جامعة عين شمس - كلية الطب - قسم الرعاية المركزية
الفهرس
Only 14 pages are availabe for public view

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Abstract

A
cute Coronary Syndromes considered as large burden of mortality and morbidity through over the world & considered as most common cause of death. ACSs including both types of MIs (STEMI & NSTEMI) critically related to time of presentation, early detection & early management as a life threatening condition & for saving the heart as the old historical word ” Time means myocardium ”.
Our study was conducted to 15 CKD patients that developed AMI and compared to another 15 CKD patients without any evidence of cardiac insults as a control group. Both sMICA & TnI were measured at zero hour in both groups. Then in AMI group both of markers were measured serially at3, 6, 12 and 24 hours recording their pattern of raising, peaking & declining.
The results were statistically analysed and revealed that sMICA levels were low in both groups at zero hour then raised in AMI group early and peaked at 3 and 6 hours then rapidly declined at 12 hours and restored its baseline levels at 24 hours. However, TnI levels were raised in both group at zero hour and started to raise in AMI group above the reference value for AMI diagnosis late than sMICA at 6 hours then peaked at 12 hours.
This results were impressive as sMICA might be considered an early marker for AMI diagnosis that raised early before TnI. However, TnI increased in both groups but sMICA not increased significantly in control group that’s add a specificity advantage to sMICA on cardiac troponin.