الفهرس 
Hepatitis C VirusOnly 14 pages are availabe for public view
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Abstract
H
epatitis C infection is a disease with significant global impact, about 130-150 million people chronically infected with the hepatitis C virus (HCV), representing about 2-2.5% of the world’s population. In Egypt, the prevalence is 10% and according to the last DHS in 2015 it was 7%.
The prognosis and management of chronic liver diseases greatly depend on the amount and progression of liver fibrosis with the risk of developing cirrhosis. Liver biopsy, traditionally considered as the reference standard for the staging of fibrosis, has been challenged over the past decade by the development of novel noninvasive methodologies.
Elastography has been used to evaluate liver stiffness for more than 10 y. As chronic liver damage results in hepatic fibrosis, characterized by an increase of extracellular matrix produced by fibroblast-like cells, the liver becomes stiffer than normal. Elastography can be used to assess liver stiffness non-invasively. Transient elastography is a 1-D technique performed with the FibroScan system (Echosens, Paris, France)
New DAAs drugs have been introduced over the past few years and a combination of two of these drugs; namely sofosbuvir and daclatasvir, are widely used in Egypt nowadays.
This study was conducted in co-operation between Gastroenterology and Hepatology Department, Ain-Shams University and the Gastroenterology and Hepatology Department, Theodor Bilharz Research Institute from January 2019 to September 2019. It included 103 adult Egyptian patients who received SOF/DAC for three months and were assessed before and after achieving SVR-24.
The patients were recruited from the outpatient clinic of Theodor Bilharz Research Institute Hospital (after consents were obtained).
All patients were subjected to; full history taking, thorough clinical examination, laboratory investigations and pelvi-abdominal ultrasound using Hitachi, EUB-5500 Equipment and Transient Elastography using echoscence 502fibroscan before receiving the treatment and after achieving SVR-24.
Child-Pugh score and FIB-4 score were calculated for all the patients.
Concerning the gender distribution in this study, male to female percent was 48.5% and 51.5% respectively and the age ranged from 25 to 70 with mean 52.4.
Our study showed that SVR-24 was associated with improvement of LSM assessed by Transient Elastography and application of FIB-4 score and overall improvement of liver biochemistry as shown by reduction of AST, ALT and serum bilirubin and increase of serum albumin and platelets.
The study also showed despite the fact that results were accompanied by significant improvement in LSM, Fib-4 and liver biochemistry, SVR-24 did not guarantee improvement of cirrhosis; only 29% of cirrhotics regressed to sub-cirrhotic range (LSM <12.5 kPa)