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العنوان
Monitoring and controlling of bacteria in pharmaceutical industries water system \
المؤلف
Selim, Nancy Ahmed Abdelrady.
هيئة الاعداد
مشرف / نانسي احمد عبد الراضي سليم
مشرف / محمد خالد ابراهيم
مشرف / على محمد على سعيد
مناقش / محمد خالد ابراهيم
تاريخ النشر
2021.
عدد الصفحات
171 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
علم الأحياء الدقيقة
تاريخ الإجازة
1/1/2021
مكان الإجازة
جامعة عين شمس - كلية العلوم - الميكروبيولوجي
الفهرس
Only 14 pages are availabe for public view

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Abstract

Water samples were collected and examined from pharmaceutical water system in a pharmaceutical factory in Giza, Egypt through twelve months, once per month, (from December 2017 to November 2018) from 15 points covering all stages of the treatment process starting from wells, pretreatment points; treatment points ending with purified points which are the main source of water used in all pharmaceutical processes. Two hundred and sixteen water samples were collected and examined for bacteria, 156 isolates were selected according to morphological characteristics. VITEK system 2 (BioMérieux) ‎was used for identification of all bacterial isolates resulting to 24 different identified bacteria. Antibiotic assay test using disc diffusion method was carried out using seven antibiotics resembling different antibiotic groups. Several disinfectants were also examined for efficacy against the isolates to control microorganisms in water treatment stage and manufacturing area. The effect of different preservatives (parabens, acids and alcohols) in various pharmaceutical formulas was also tested on bacterial isolates, 63% of formulas were effective against all bacterial isolates.