الفهرس 
REVIEW OF LITERATURE
Renal histopathological AssessmentOnly 14 pages are availabe for public view
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Abstract
Background & Aim: Diabetic nephrectomy (DN) is a chronic
progressive disorder that complicates long standing diabetes.
Albuminuria is a prominent clinical feature of DN.
Ursodeoxycholic acid (UDCA) is a physiologic hydrodrophillic
bile acid that is therapeutically used in the treatment of primary
biliary cirrhosis and is known to alleviate endoplasmic reticulum
(ER) stress in podocytes. In comparison to ramipril as a standard
ACEI therapy of DN, the present study was designed to
investigate the effect of UDCA treatment on DN in association
with renal biomarkers changes. Method: Four groups of male
Wister rats were designed; Normal control group, DN untreated
group (High fat diet + STZ injection of 45 mg/kg +
uninephrectomy), DN/Ramipril group; (1 mg/kg/d orally for 12
weeks) and DN/UDCA group (40 mg/kg/d orally for 12 weeks).
Results: DN rats treated with UDCA for 12 weeks exhibited
significant decrease in ER stress marker, ATF6 with mean
percentage value of 73.8% and improvement of podocyte
structural deformities that is accompanied by a significant
reduction in albuminuria by mean percentage value of 43.8% in
comparison to DN untreated group. Ramipril treated animals
showed reduction in ATF6 level by 65.5% and reduction in
albuminuria by of 50.2% in comparison to DN untreated group. The remarkable improvement in metabolic profile and the neutral
effect on blood pressure in UDCA treated group could explain the
renoprotection at histopathological basis rather than the proved
hemodynamic effect of ramipril. Conclusion: Participation of ER
stress-mediated apoptosis in the pathophysiology of diabetic
nephropathy make the UDCA a potential therapeutic option or
add-on therapy due to its anti-apoptotic property apart from classic
metabolic and hemodynamic aspects.
Key words: Diabetic nephropathy; ER stress; Albuminuria;
UDCA; Ramipril.