الفهرس 
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Abstract
The liver is the largest and vital organ in the body and have much important and essential function. It is the largest gland organ with high regenerative capacity.
Liver diseases is a major health problem worldwide especially in Egypt. Hepatic diseases is a term generally use for conditions, diseases, and infections that affect the cells, tissues, structures, or functions of the liver.
Schistosoma mansoni infection is associated with hepatic fibrosis and portal hypertension. Previous studies reported that blocking some components of rennin angiotensin system can ameliorate the liver pathology induced by S. mansoni Infection.
The present study investigated the potential effect of losartan, an angiotensin II receptor antagonist, and enalapril, an angiotensin-converting enzyme inhibitor, on hepatic fibrosis caused by S. mansoni in a murine model.
S. mansoni-infected mice were treated at week 5 after infection with losartan, enalapril, or their combination. A group of infected mice was treated with
the reference drug praziquantel (PZQ) as controls. Parasitological and histological
parameters were investigated.
Our results showed that when compared with enalapril, treatment with losartan alone caused a considerable decrease in liver index, spleen index, worm burden hepatic tissue egg load, granuloma size and fibrosis. The combination of losartan and enalapril did not produce a more pronounced effect than those of losartan. Results show that Enalapril and losartan have antischistosomal effect.
Our results suggest the promising effect of enalapril and losartan in amelioration of hepatic pathology but further studies to determine their effects in combination with other antischistosomal agents such as praziquantel are recommended.