الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 175 |  |  |
| | | from | 175 | | |
Abstract
K. pneumoniae is an opportunistic MDR pathogen, which may
result in difficult treatment of human and animal infections due to poor
antibiotic response. K. pneumoniae biofilms can lead to colonization in
the respiratory, gastrointestinal, and urinary tracts, as well as the
development of invasive infections. It also plays an important role in
pathogenicity and chronigenicity of K. pneumoniae infections.
This study was conducted to investigate the prevalence of MDR
klebsiella isolates in animal and human sources in Egypt. Further, to
evaluate the possible correlations between the antibiotic resistance of K.
pneumoniae isolates and their ability to form biofilms.
The bacteriological investigations revealed that K. pneumoniae was
recovered from 23 out of 200 samples with an overall prevalence of
11.5%.Thirteen of the isolates were recovered from 150 analyzed samples
from animal sources (8.67%) comprising chicken organs (n=6/50; 12%),
meat products (n= 3/25; 12%), milk products (2/25; 8% ), and raw milk
(1/25; 4%). The other 10 isolates were recovered from 50 samples from
human sources (20 %) comprising 28% (7/25) from sputum samples and
12% (3/25) from urine.
This study highlights the most alarming situation of highly diverse
antibiotics resistance. In this study, the antibiogram of K. pneumoniae
isolates revealed absolute resistant to ampicillin and amoxicillin
clavulnate (100% each), followed by ceftazidime (95.65%), trimethoprim
sulfamethoxazole (86.95%) and cefepime (73.91%). However, moderate
susceptibility level to ofloxacin (60.86%) followed by imipenem
(56.52%) were observed. Interestingly, a high sensitivity level was
observed for colistin (95.65%, MIC range = 0.25 - 2 μg/mL), while only.