الفهرس 
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Abstract
Tuberculosis (TB) is a severe air transmitted infectious diseaseca used by bacillus Mycobacterium tuberculosis(Mtb) bacteria and causes significant worldwide mortality.
Dihydropyrimidine ring is found in various heterocyclic structures theyare among the most promising scaffolds for the design of new anti-TB drugs.
The search for new drug targets is gaining great interest in modern medicinal chemistry. In this context, TMPK mtrepresents an attractive promising target for developing new drugs against tuberculosis.
Motivated by these facts and as a continuation of our research on heterocyclic chemistry aiming to find new structure leads which might be of value for development of new more potent antimycobacterial agents, with higher safety profile, the present investigation was directed to design, synthesize and biologically investigate a new series of dihydropyrimidine derivatives as TMPK mtinhibitors.