الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
It has been noticed that pyridine derivatives whether free or fused with other rings constitute a crucial scaffold with numerousreported biological activities.
Pyridine moiety was considered as an important structure fragment in different medicinal chemistry classes such as anticancer, antimicrobial, anti-inflammatory, antiviral, analgesic, antihistaminic and cardiotonic agents.
These facts encouraged us to design and synthesizenovel lead structures containing pyridine ring substituted or fused with heterocyclic rings as potent anticancer PIM-1 kinase inhibitors.
The newly synthesized compounds were screened for their anticancer activities and the most active compounds were evaluated for their PIM-1 kinase inhibitory activity.