الفهرس 
Chapter IOnly 14 pages are availabe for public view
Abstract
Novel three Schiff base compounds, their complexes with Co(II), Ni(II), Cu(II), Zn(II), Cd(II) ions and Cu nanocomplexes were prepared and characterized by elemental, thermal analyses and spectroscopic techniques. The data showed that complexes have octahedral geometry and square-planar geometry. 3D Molecular modeling study was reported to gain better insight on the molecular structures of ligands and some of their metal complexes. The ligand and some metal complexes were screened as an antitumor agent towards Hepatocellular carcinoma cell line (HepG-2). The DNA cleavage activity of some Cu nanocomplexes was studied by using agarose gel electrophoresis. The results of DNA cleavage studies showed that important role of Cu nanocomplex in isolated DNA cleavage reaction. Also, The molecular docking studies of the free ligands and their Cu(II) complexes were reported and the results of this study have widened the scope of developing these sulphachloropyrazine compounds as promising antitumor drugs.
The ligands and some complexes showed antimicrobial activity against selected kinds of bacteria, yeast and fungi. Results of analyses indicated that free ligands and their metal complexes are antibacterial and anticancer materials. The electrical conductivity of free ligands and some Cu nanocomplexes was studied and the data revealed that semiconductor behavior for these nanocompounds.