الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
Favorable treatment outcome is depending on accurate detection of meningitis etiological agent. Lately, increasing significance is attributed to the role of cytokines in bacterial meningitis differentiation. Herein, we aimed to evaluate the diagnostic significance of tumor necrosis factor alpha (TNF-α) and interleukin- 10 (IL-10) in Haemophilus influenza type b (Hib) meningitis. Ninety-six patients clinically suspected of bacterial meningitis (60 with Hib and 36 with non-Hib meningitis) were enrolled in this study. CSF and serum level of TNF-α and IL-10 were quantified by ELISA. Diagnostic performances of each cytokines were evaluated using area under ROC. Significant increase in IL-10 and TNF-α levels was noted in both CSF (P=0.004 and 0.009; respectively) and serum (P=0.007 and 0.010; respectively) in Hib meningitis patients compared to non-Hib meningitis patients. IL-10, and TNF-α had a discriminative capability for Hib meningitis in CSF (AUC=0.75 and 0.77; respectively) as well in serum (AUC=0.72 and 0.78; respectively). In conclusion, TNF-α and IL-10 cytokines are potential biomarkers for differentiating Hib meningitis from meningitis causing by other bacterial agents particularly in serum, less invasive sample, to help or even replace lumbar puncture.