الفهرس 
Introduction and Aim of the WorkOnly 14 pages are availabe for public view
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Abstract
Post-burn scars have functional and cosmetic influences on affected individuals due to their aberrant wound healing. A healed burn patient may be left with scars and disfigurement which have down effects on self-esteem, body image and overall quality of life.
Burn scars have, in addition, some functional morbidity such as contractures, hypertrophic changes and keloid formation. Furthermore, burn scars could produce persistent hyperemia, chronic folliculitis, intense and unrelenting pruritis and neuropathic pain.
For more than 25 years, laser therapy has been used for the treatment of scars; in the medical literature there are different laser and light-based technologies that are poised to dramatically alter our reconstructive algorithm and create a major paradigm shift in the management of burn scars.
The aim of this work was to evaluate the efficacy of fractional CO2 laser in the treatment of burn scars clinically, histometric, and histopathologically.
Our results showed that,
Before treatment, the median value of Vancouver Scar Scale was 2,2, 3.5 &3 for Pigmentation, Vascularity, Pliability and Height respectively. with significantly decreased to 2, 1, 1&1 respectively after treatment (p<0.001 for all).
Before treatment, the median value of Observer Scar Assessment Scale was 6,8,7.5,8&7 for Vascularization, Pigmentation, Thickness, Relief and Pliability respectively. with significantly decreased to 3, 6, 3, 3 &3 respectively after treatment (p<0.001 for all).
According to Patient Scar Assessment Scale, there was significant difference between before and after the treatment patient’s observation regarding scar irregularity, stiffness, color difference and thickness difference (p<0.001 for all). On the other hands, no significant difference in scar pain and itching (p=0.109 for all).
H & E Grading Score of collagen fibers before the treatment was 4 and significantly decreased to 1 after the treatment (p<0.001).
By Histometric assessment, Epidermal Thickness before treatment was 99.8 and insignificantly decreased to 84.1 after treatment (p=0.145). on the other hands, Dermal Thickness significantly increased from 1500.1 before treatment to 1836.7 after treatment (p<0.001).
In conclusion,
Fractional CO2 laser can be an effective and safe modality in the treatment of post-burn scars. It achieves significant change in the opinion of the patients about their scar appearance.
So, fractional CO2 laser seems to be an encouraging approach in the treatment of scars, not only for its efficacy, but also for its low harmfulness.
Data shown here can expand our knowledge in scar treatments to aid burn patients through new therapies.