الفهرس 
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Abstract
Background: COPD exacerbations are heterogeneous in terms referred to airway inflammation by different etiology. It contributors to impaired lung function and quality of life, in addition to emergent healthcare use and mortality burden.
Objectives: To evaluate the correlation of blood and sputum eosinophils count with COPD exacerbation severity as a primary outcome, then reporting the impact of steroid use in patients with higher eosinophils counts as a secondary endpoint.
Subjects and Methods: 100 COPD cases were evaluated in outpatients clinic and inpatients words depending on their characters of exacerbation, and subjected for blood and sputum sample collections to estimate the level of eosinophils; once at examination and one more time after regular treatment protocol.
Results: Repeated hospital admission from COPD exacerbation was significantly correlated with eosinophils level in blood and sputum; (r = 0.29; P = 0.003 and r = 0.3; P = 0.002) respectively. Moreover, the level of eosinophils in blood and sputum was significantly higher in severe exacerbation groups, P < 0.001 and lower in groups treated with steroid therapy; P < 0.001 and 0.004 respectively.
Conclusion: Eosinophils either in blood or tissue could be used as a biomarker for evaluating COPD exacerbation severity, besides, it could guide the treatment by steroid therapy.