الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
(SLE) is a disease characterized by excessive proinflammatory cytokine production and damage to multiple organ systems. STAT3 also plays key roles in Th17 lymphocyte development and differentiation as it binds to and regulate multiple genes that contribute to the Th17 phenotype, including the IL17 locus, IL21 and IL23r. Objective: to investigate the role of IL-17F (rs763780), STAT3 (rs2293152) gene Polymorphisms with risk of association to SLE in Egyptian population, also to evaluate their correlations with disease activity. Methods: PCR-RFLP technique was used for IL-17F and STAT3 genotyping, for 100 SLE patient and 100 age and sex matched healthy controls. Results: IL17F AG, AG+GG genotypes, STAT3 CC, CG+CC genotypes had higher frequency in cases when compared to control group (p=0.038, 0.046, 0.014, 0.046 respectively); with risk to develop SLE (OR=1.477, 1.431, 1.857, 1.474 respectively). Logistic regression analysis was conducted for prediction of SLE shows IL17F and STAT3 combined polymorphic genotypes were considered independent predictors of SLE development in uni- and multivariable analyses. Ordinal regression analysis was conducted for prediction of activity (higher SLEDAI) within SLE patients, Low C3 was significantly associated with higher risk of increased activity. Conclusion: IL17F rs763780 AG, AG+GG genotypes & STAT3 rs2293152 CC, CG+CC genotypes had risk to develop SLE in Egyptian population, and were independent predictors of SLE development. IL17F rs763780 and STAT3 rs2293152 had no relation to demographic, laboratory and clinical data. IL17F rs763780 and STAT3 rs2293152 had no relation to SLE activity. Only low C3 in the current study considered as predictor of increased activity.