الفهرس 
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Abstract
Cow’s milk protein allergy is defined by the world allergy organization as a hypersensitivity reaction against cow’s milk. This reaction to one or more milk protein: α-lactalbumin, β-lactoglobulin, casein, ige or non-ige is associated with immediate and late onset symptoms(6).
IgA play a significant role in protection against food allergy but the relationship between its level in breast milk and cow milk allergy is poorly understood, and the results from different studies are controversial. Several studies found a relationship between total IgA levels in colostrum and human milk and subsequent development of CMPA(144).
This study was an analytical cross-sectional study conducted to determine the content of total IgA in human milk in relation to the subsequent development of CMA in the exclusively breast-fed infant.
This was achieved throughassessing the correlation between total IgA level ofbreast milk and theincidence of cow milk allergy in exclusively breastfed infants and assessment of the difference between total IgA level in breast milk of mothers of atopic infants and those with non atopic infants.
The study showed the following results:
1. The mean age of the sample was 4.44 ± 1.38 months. Males formed 48% of the infants while 52% of them were females. The mean weight and BMI of cases with cow milk allergy was significantly lower than that of the controls (p=0.02) and (p<0.001), respectively.
2. There was no reported history of intrauterine infection or neonatal jaundice in both groups. In atopic infants group, only one case reported NICU admission and neonatal complications.