الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Imidazoles are important class of heterocyclic compounds which are major constituent of several naturally occurring compounds (e.g., histamine, histidine, biotin, alkaloids and nucleic acid). Within this context, vast number of imidazole-based derivatives has been developed for different therapeutic actions, due to their biological relevance.
Imidazole derivatives (x-y) were synthesized via the reaction of oxazolone 2 with different amines namely 3-amino-1,2,4-triazole, benzocaine, 4-aminoantipyrine, 2-aminothiazole and p-aminoacetophenone and their chemical structures were confirmed employing different analytical and spectroscopic methods.
Furthermore, the reactivity of the imidazole ester derivative 19 were further studied by reaction with different amines. Reaction of 19 with thiosemicarbazide afforded the corresponding thiosemicarbazone derivative 20 in good yield. Moreover, cyanoacid hydrazide derivative 22 was prepared by condensation of imidazole derivative 19 with hydrazine hydrate and then with ethyl cyanoacetate.
Furthermore, we directed our attention for another type of heterocyclic compound: saccharin. The latter was used for the synthesis of different saccharin derivatives (25-31) with expected biological activities starting from the sodium salt of saccharin and employing the Mannich multi component reaction. In this reaction the sodium salt of saccharin was allowed to react with formaldhyde and different secondary amines (e.g., methyl amine, diethyl amine, morpholine in addition to different aniline derivatives). The corresponding Mannich bases was constantly observed and this was confirmed using the different spectroscopic and analytical techniques.
whether any of the synthesized compounds may be useful for further investigations, the toxicity of the compounds was evaluated against the susceptibility of the laboratory strain of the 2nd instar larvae of the cotton leafworm S. littoralis (Boisd.)