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العنوان
Effect of Lactoferrin Supplementation
on Appetite and Weight Loss in Obese
School Age Children /
المؤلف
Emara, Islam Samy Ali AbdEl-Ghany.
هيئة الاعداد
باحث / إسلام سامي علي عبدالغني عمارة
مشرف / هدي لطفي السيد
مشرف / ماريان جرجس رزق
مشرف / ماريان جرجس رزق
تاريخ النشر
2020.
عدد الصفحات
148 P. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
طب الأطفال ، الفترة المحيطة بالولادة وصحة الطفل
تاريخ الإجازة
1/1/2020
مكان الإجازة
جامعة عين شمس - كلية الطب - قسم طب الاطفال
الفهرس
Only 14 pages are availabe for public view

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from 148

Abstract

O
besity in children is considered the most prevalent nutritional disorder among children and adolescents in many countries. Minor and major problems may arise in children and adolescents with obesity; most of these problems have considerable impact on quality of life, and some may reduce life expectancy. Many factors, including genetics, environment, metabolism, lifestyle, and eating habits, are believed to play a role in the development of obesity. However, most of cases are idiopathic.
There are complex homeostatic mechanisms that tightly regulate appetite and body weight. Obesity is a state in which energy intake chronically exceeds energy expenditure mainly due to increased appetite and lack of physical exercise. Many factors affecting appetite in obese children including changes in appetite control neural pathways, gastric emptying, gastric motility sensitivity, satiety responsiveness, peripheral adiposity signals, changes in plasma levels of gut hormones and gut microbiota.
Lactoferrin is a protein that derived from bovine and human milk and has many biological and immunological effects and uses. One of its biological roles is its effect on appetite and obesity.
Leptin is an adipocyte-secreted hormone which plays a key role in energy homeostasis and has an effect on obesity by regulation of expression of hypothalamic neuropeptides.
We aim in this study to determine the effect of lactoferrin intake on appetite and weight loss in obese school age children. Also this study aims to determine the effect of lactoferrin intake on serum leptin level and lipid profile in serum in obese school age children.
This study was a randomized double armed prospective clinical trial study which included 50 obese school-aged Egyptian children with an age range of 6 to 12 years old following up at the Pediatric Nutrition Clinic of Ain Shams University hospitals.
Those children have divided into two equal groups. The first 25 children have received oral lactoferrin supplementation for 12 weeks in addition to diet regimen and exercise performance and named as ”Lactoferrin group” (LF group).
The second 25 children did not take lactoferrin and put only on a diet regimen and exercise program for the same 12 weeks and named as ”Non- Lactoferrin group” (Non-LF group).
All children of our study were subjected to full history taking including dietetic history (24 hour dietetic recall and CEBQ), examination including anthropometric and body composition measurements and lab investigations including lipid profile and serum leptin level before and after study period.
Results Data were analyzed using IBM© SPSS© Statistics version 23 (IBM© Corp., Armonk, NY).
Our study revealed as regards anthropometric measurements no statistical significant difference in weight and BMI after intervention. As regards body composition, the study revealed a significant difference in increase of body water content between the two study groups more in LF group. However, no significant difference in body fat content between the two study groups after intervention.
As regards appetite behavior, our study showed significant difference after intervention more in LF group regarding total Food Preference subscales (significant decrease) and total Food Avoidance subscales (significant increase). This means that LF group showed less food intake behavior and more satiety response than Non-Lf group.
Regarding serum leptin level, our study revealed a highly significant difference between the two study groups regarding the change (the decrease) of leptin level that was more in LF group.
Also our study demonstrated as regards lipid profile significant difference regarding the change (the decrease) of total cholesterol which was more in LF group. However, no significant differences between the two study groups regarding changes of levels of LDL, HDL or triglycerides levels were found.
So, we can sum up to a conclusion that administration of oral lactoferrin to obese children may have no significant effect on weight and BMI when compared with those who did not take lactoferrin when taken for 12 weeks. However, lactoferrin has showed a remarkable effect on decreasing appetite, leptin serum level, adipose tissue and lipid profile and increasing HDL after 12 weeks of administration. More studies has to be done on obese children with longer period of study time and measuring other satiety hormones and other serum parameters related to obesity in response to administration of lactoferrin and other whey proteins (e.g. lactalbumin).