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Results of the present study revealed that most of CAD patients were current smokers while most of controls were non-smokers. The presence of hypertension and high BMI were statistically more common in CAD patients as compared to controls. A non-statistically significant difference was found between both groups as regards lipid profile levels.
The present study proved that the heterozygous PlA1/PlA2 genotype and PlA2 allele of PlA1/PlA2 polymorphism were more frequent in CAD patients than in the controls; however, such difference in frequency was not statistically significant. On the other hand, the homozygous PlA2/PlA2 genotype was completely absent in the studied population.
In the present study, no statistically significant association was found between the patients′ genotypes and either the number of occluded coronary vessels or CAD conventional risk factors. However, the heterozygous PlA1/PlA2 genotype was more likely to be combined with male sex and increased blood total cholesterol level.
In conclusion, the present study revealed the absence of significant differences in the genotype frequencies of PlA1/PlA2 polymorphism of the ITGB3 gene in CAD patients as compared to controls although being higher in the former group. Moreover, the different genotypes of the ITGB3 gene were not associated with CAD severity or with any separate CAD risk factor. Meanwhile, the heterozygous PlA1/PlA2 genotype tends to be more frequent in male patients who have a high blood total cholesterol level.