الفهرس 
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Abstract
T
he idiopathic epilepsies (IE) are syndromes of genetic origin. It is consisted of two groups of epilepsy: idiopathic generalized epilepsy (IGE) and Idiopathic focal epilepsy (IFE) (Berg et al., 2010).
Idiopathic generalized epilepsies include (childhood absence epilepsy, juvenile absence epilepsy, juvenile myoclonic epilepsy, and generalized tonic-clonic seizures only). In the new classification, they can be called “genetic generalized epilepsies” or “idiopathic generalized epilepsies” (Brodie et al., 2018).
Idiopathic Focal Epilepsies (IFE) before named as “benign epilepsy include atypical benign partial epilepsy (ABPE), benign epilepsy with centrotemporal spikes (BECTS or Rolandic epilepsy), and Panayiotopoulos syndrome (PS) (Pal et al., 2016).
Cognitive functions which includes processes such as intelligent thinking, perceiving, remembering, reasoning, judging, expressing, and understanding are compromised in people with idiopathic epilepsy (Lodhi and Agrawal, 2012).
Neuropsychological study of new-onset epilepsy was considered to present an exciting opportunity to document cognitive effects of epilepsy before initiation of antiepileptic drugs and to establish a baseline that would enable evaluation of changes over time. Existing studies have already shown certain cognitive deficits in children with new onset idiopathic epilepsy (Hermann et al., 2006, Rathouz et al., 2014).
Indeed, cognitive impairments often predate the first seizure. For example, about a quarter of children with new-onset idiopathic epilepsies needed support from special educational services before the onset of seizures (Lin et al., 2012).
Recent study revealed significant affection of executive functions in new onset seizure without medication (Zhang et al., 2018).
The study of the idiopathic epilepsies may be helpful in understanding the relationship between cognitive impairment and the disease-related characteristics of epilepsy (Aldenkamp, 2005).
Proper and early identification of cognitive dysfunctions in patients with idiopathic epilepsy is necessary to provide early developmental interventions, appropriate school programming, vocational counseling, supportive work settings, and a safe environment for promotion of independence across the life span (Mandelbaum et al., 2009).
Our study aimed to evaluate cognitive functions including (IQ, visual memory and executive functions) in patients with idiopathic epilepsy at onset of disorder before drug treatment or within one week of treatment and after 6 months treatment to know if there were any deficits at baseline and the outcome of results after 6 months of treatment.
Summary of findings
Comparison between patient group before treatment and control group revealed that the control group was well match to patient group regarding socio-demographic charecteristics (age, sex and years of education). While as regards cognitive functions; we found statistically significant poor performance of patient group before treatment on all parameters of Wechsler IQ test, Benton visual retention test and Wisconsin card sorting test.
Comparing results of cognitive function tests in patient group as regards different types of epilepsy revealed no significant difference between different groups of diagnosis.
Comparing results of cognitive function tests in patient group as regards (sex, family history of epilepsy and family history of consanguinity) revealed only sssignificant lower scores of similarities and picture completion (IQ test) in patients with positive FH of consanguinity than patients with negative FH of consanguinity.
Comparing results of cognitive function tests between patient group before treatment and patient group after 6 months of treatment revealed significant improvement of IQ, visual memory and executive functions.
Comparing results of cognitive function tests between seizure free patients and not seizure free patients after 6 months of treatment revealed significant better performance of seizure free group than not seizure free group across all cognitive domains.
Comparing results of cognitive function tests between groups of treatment in patients after 6 month of treatment showed significant better performance as regards executive functions (perseverative errors, perseverative errors%, perseverative response and perseverative response%) in levetiracetam only group followed by sodium valproate only group with worst performance in combination group (sodium valproate and levetiracetam).
Correlation between results of cognitive function tests of patient group before treatment and socio-demographic data We found that age in years was positively correlated with similarities (IQ test), Years of education was positively correlated with similarities (IQ test) and negatively correlated with digit span (IQ test), perseverative responses and Perseverative responses% (Wisconsin card sorting test).
Correlation between results of cognitive function tests of patient group before treatment and clinical characteristics of seizures.The age at onset was positively correlated with similarities (IQ test) and negatively correlated with expected error scores (EES) (Benton Visual retention test), perseverative responses and perseverative responses% (Wisconsin card sorting test).