الفهرس 
Vaccine overviewOnly 14 pages are availabe for public view
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Abstract
Vaccination is the most effective method of preventing infectious diseases; widespread immunity due to vaccination is largely responsible for the worldwide eradication of smallpox and the restriction of diseases such as polio, measles, and tetanus from much of the world.
Meta-analysis is an epidemiological technique for summarizing and reviewing previous quantitative research, by using meta-analysis.
The aim of the present study is to establish evidence based knowledge of the immunity of healthy children against viral vaccines and establishing guidelines for viral vaccines programs
Methodology: According to guidelines outlined by the preferred reporting items for systematic review and meta-analysis (PRISMA) statement, the researcher made the research in Medline, Eulc, Epic and other databases which were published in the last ten years.
The researcher reviewed the theses, papers, journals, in Egyptian studies in English language, searching for the eligible studies.
The researcher visited the libraries (central and digital) in the medical faculties and nursing faculties as well, nutritional institute in Cairo, national research center in Cairo. The visited universities were, Cairo, Ain Shams, Azhar, Banha, Zagazig, Tanta, Shibin El-Kom, Mansoura, and Alexandria Universities. The researcher collected data from theses of Msc., MD., PHD which focus on evaluating immunologic response of vaccines against viral diseases.
43 studies were found, which focused on evaluating immunologic response of vaccines against viral diseases, fulfilled the inclusion criteria and located within the assigned time of research. Meta-analysis was done using MedCalc software ver. 12.7.7.0.
Results:
Regarding hepatitis B virus vaccine, 33 studies were included with a total number of 9611 healthy Egyptian vaccinated child. The proportion of seroprotected Egyptian children with HBs antibodies ≥10 mIU/ml, was 66.13%., the proportion of children with positive HBc antibodies was 2.81%, the proportion of children with positive HBs antigen is 0.64%. the mean HBsAb titer increased after booster dose by 267.96±232.95 mIU/ml.
Regarding measles, mumps and rubella vaccine, 10 studies were included, with 1141 cases. The proportion of seroprotected Egyptian children with measles antibodies is 80.74%. The proportion of seroprotected Egyptian children with mumps antibodies is 45.06%. The proportion of seroprotected Egyptian children with rubella antibodies is 90.21%