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العنوان
Assessment of Growth and Nutritional Status in Children
with chronic Liver Diseases and Their Relation to
Serum Level of Insulin-Like Growth Factor -I /
المؤلف
Mohamed,Hany Fathy Ahmed.
هيئة الاعداد
باحث / Hany Fathy Ahmed Mohamed
مشرف / Ehab Mohamed Eid
مشرف / Moushira Erfan Zaki
مشرف / Rokaya Mohamed El-Sayed
تاريخ النشر
2014
عدد الصفحات
154p.;
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
طب الأطفال ، الفترة المحيطة بالولادة وصحة الطفل
تاريخ الإجازة
1/1/2014
مكان الإجازة
جامعة عين شمس - معهد الطفولة - صحة و تغذية الطفل
الفهرس
Only 14 pages are availabe for public view

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Abstract

The aim of this study was to evaluate growth and nutritional status of children
with CLD & to measure the level of IGF-1 and to identify the relation between its
level to both the degree of malnutrition and the degree of hepatic dysfunction. This
study included 50 Egyptian children (25 males and 25 females) recruited from the
outpatient clinic of pediatric hepatology and from pediatric hepatology department of
Pediatric Hospital, Cairo University. Their mean age was 2.05 years (ranged from 0.6
-5.75 years). Laboratory results were compared to 50 age and sex-matched children
(control group). Anthropometric measurements, liver functions tests, serum level of
IGF-1 & 25 (OH) D were performed to all subjects. Our results revealed that 54% of
the patients were short, while malnutrition was identified in 70% of patients by
TUAA, 62% by MUAC, 56% by TSFT, 56% by SSFT, 52% by MUAFA, 46% by
MUAMA, 42% by Wt, 30% by Wt/Ht, and 22% by AFI. Moreover, MUAC was the
most affected anthropometric parameter followed by TUAA, TSFT, MUAFA, Wt,
MUAMA, SSFT, AFI, Wt/Ht respectively. Also, results showed that TSFT, SSFT and
AFI z scores were significantly lower in Child Pugh C compared to Child Pugh B and
A, and were significantly lower in Child Pugh B compared to Child Pugh A. In
addition, Wt, Wt /Ht, MUAC, TUAA, MUAMA, and MUAFA z scores were
significantly lower in Child Pugh C compared to Child Pugh A. Moreover, TUAA,
MUAC, MUAMA, TSFT, SSFT, MUAFA and AFI z scores were significantly
depressed in cholestatic group when compared to non cholestatic group, and were
significantly depressed in children aged < 2 years old when compared to children
aged ≥ 2 years old. Concerning serum IGF-1 & 25 (OH) D levels, both were
significantly lower in patients compared to controls, and were significantly lower in
Child Pugh C compared to Child Pugh B and A, and were significantly lower in Child
Pugh B compared to Child Pugh A. Also, no significant correlation was found
between any of the anthropometric parameters and serum IGF-1. It was concluded
that growth retardation and malnutrition are common complications in children with
CLD particularly when the liver disease is cholestatic, its onset is in infancy and with
progression of liver disease severity. Moreover, it was concluded that the best
anthropometric parameters, that can identify malnutrition in these patients, were
TUAA, MUAC and TSFT. Also, in CLD patients, IGF-I level was reflecting the
degree of liver dysfunction rather than the degree of malnutrition.