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العنوان
Vitamin D-binding protein in cervicovaginal fluid as a non-invasive predictor of maternal and fetal outcome in women with preterm labor/
المؤلف
Abd-Alla, Mohammed Ahmed Khairy.
هيئة الاعداد
باحث / Mohammed Ahmed Khairy Abd-Alla
مشرف / Ahmed Ramy Mohamed Ramy
مشرف / Mohamed Mahmoud El-Sherbeeny
مشرف / Rehab Mohamed Abdelrahman
تاريخ النشر
2019.
عدد الصفحات
135 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
أمراض النساء والتوليد
تاريخ الإجازة
1/1/2019
مكان الإجازة
جامعة عين شمس - كلية الطب - أمراض النساء والتوليد
الفهرس
Only 14 pages are availabe for public view

from 135

from 135

Abstract

Spontaneous preterm labor and intact membranes (PTL) accounts for approximately 70 to 80% of all preterm births, and preterm birth, owing to these causes in particular, is strongly associated with significant neonatal morbidity, mortality, and long-term disability.
Vitamin D-binding protein (VDBP) is a 58-kDa protein of the albumin superfamily that is mainly synthesized by hepatocytes. The established functions of VDBP include acting as a major carrier protein for vitamin D and its metabolites in serum, sequestering actin, and potentially modulating the inflammatory and immune response, and it is associated with the clinical progression of many diseases. In particular, previous studies that used the proteomic and cohort approaches have shown significantly increased expression of CVF VDBP in association with the occurrence of impending PPROM in asymptomatic women and of SPTD and intra-amniotic infection in women presenting with symptoms of PTL. However, these findings have not been confirmed by other studies. Moreover, whether the change in VDBP level in the CVF is associated with intra-amniotic infection and impending SPTD in women with PPROM remains unclear. Hence, the aim of this study was to determine whether the level of VDBP in CVF samples is independently predictive of SPTD within 48 hours in women with PTL.
In the multivariable analysis, elevated VDBP levels in CVF samples of PTL women were significantly associated with imminent preterm delivery, even after adjusting for potential confounders (e.g., gestational age at sampling, parity, and serum CRP). In women with PTL, the areas under receiver operating characteristic curves of CVF VDBP level for predicting imminent preterm delivery were 0.781, with cut-off values of 2.3 μg/mL (sensitivity of 63.16% and specificity of 96.0%). respectively. The CVF VDBP levels were significantly high in women with PTL.
Conclusions: VDBP in the CVF independently predicts imminent preterm delivery in women with PTL.