الفهرس 
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Abstract
Diabetic macular ischemia is a not only a vision-threatening complication of
diabetic retinopathy (Mansour et al. 1993), but also affects the response to
treatment and the final visual outcome (Jonas et al. 2005, Chung et al. 2008).
FFA is the current gold-standard in the diagnosis and management of
diabetic retinopathy (ETDRS 1991a). However, besides its invasive nature, its
utility in DMI is limited by its inability to view the intra-retinal vascular
networks separately, and by the dynamics of dye transit (such as leakage) which
may obscure or superimpose areas of ischemia and the borders of the FAZ (de
Carlo et al. 2015).
OCTA has the ability to rapidly and non-invasively form segmented images
of the macula, allowing visualization of each vascular plexus separately. The
vascular flow maps are generated by split-spectrum amplitude-decorrelation
angiography (SSADA) which utilizes a motion contrast technology able to
detect the flow of RBCs through the intra-retinal capillaries (Jia et al. 2012).
We decided to conduct this cross-sectional study on 63 diabetic and 11
control eyes. DMI was quantified in OCTA images of the SCP, ICP, and DCP
using four parameters, namely FAZ area, FAZ CI, VAD and VLD. These
parameters were then correlated with LogMAR BCVA, age, controls versus
diabetics, and duration of diagnosis of DM. Also ICC was calculated between
manual and automated measurements and between two graders for ten eyes.
We considered our results to be reliable in light of the high ICC recorded
between graders and between manual and automated measurements.
CI, and VAD were able to differentiate diabetics from non-diabetics.
Automated CI was consistently correlated with LogMAR BCVA in diabetic
eyes. However, a higher significance was achieved on combination of CI with
the other automated parameters.
Therefore, OCTA can reliably measure ischemia in diabetic eyes and can
correlate these measurements with visual acuity. Further prospective study to
investigate the prognostic significance of these results is warranted.