الفهرس 
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Abstract
The incidence of postoperative atrial fibrillation (POAF) varies according to the type of surgery. Postoperative atrial fibrillation (POAF) is the most commonly observed arrhythmia after coronary artery bypass grafting (CABG) and is associated with increased morbidity, mortality and prolonged hospitalization due to hemodynamic instability and thromboembolic complications. Magnesium seems to be with great promise to prevent POAF following CABG. Dronedarone is a drug mainly for the indication of cardiac arrhythmias. It was approved by the FDA on July 2, 2009. It was recommended as an alternative to amiodarone for the treatment of atrial fibrillation.
Aim of the work:
The aim of the study is to conduct a comparative study between magnesium sulphate (Mgso4) versus Dronedarone reducing incidence of atrial fibrillation after coronary artery bypass grafting.
Patients and methods:
This study was a comparative study that performed in the cardiac operating room and ICU of Ain-shams university Hospitals. The study was performed on 60 patients who had undergone successful CABG. The local Ethics Committee approved of the study, and personal informed consent was taken.
Methods of drug administrations, dosages will be assessed. Also, Specific clinical interventions and follow-up was determined. The primary outcome was incidence of postoperative AF. Supraventricular arrhythmias other than AF (e.g. tachycardia’s and atrial flutter) and all other nonatrial arrhythmias were excluded.
Results:
Sixty patients were included in this study; they were divided into two groups. First group were patients who received MgSO4 sulphate perioperative and second group were patients who received Dronedarone. There were no statistical difference among the both groups in terms of demographic, comorbidities, clinical and laboratory parameters. Incidence of AF was more common in 2nd group (36.7%) versus (23.33%) in first group with significant statistical difference between both groups (p=0.021).
Conclusion
Postoperative AF is a common complication for contemporary patients undergoing CABG. The use of Mg to prevent AF after CABG was statistically significant and appears to reduce risk of atrial fibrillation after cardiothoracic surgery and is free of significant adverse events. Also, the low cost and minimal risk of magnesium therapy suggest the need for magnesium administration to patients after cardiothoracic surgery.