الفهرس 
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Abstract
SUMMARY
T
he ability to determine the degree of the liver steatosis and fibrosis as well as to predict the progression of disease is essential in the management of patients with NAFLD. A liver biopsy has been used as a gold standard for this purpose over many years. However, its invasive nature, high cost, and risk for development of severe complications (bleeding in particular) resulted in the development of noninvasive tests. These tests consist of different scores derived from various combinations of serologic markers as well as noninvasive imaging modalities.
In this case control comparative study we wanted to measure the MPV in 100 Egyptian adults with nonalcoholic fatty liver disease (NAFLD) in both diabetic and non-diabetic patients and 50 apparently healthy adults’ age and sex matched as a control group.
We found that;
1. Platelet count (PC) was significant lower in NAFLD cases compered to control.
2. MPV in NAFLD was significantly higher in NAFLD cases than control group.
3. Platelet / Lymphocytes ratio (PLR) and Neutrophil / Lymphocytes ratio (NLR) were highly significant lower in NAFLD compared to control.
4. Platelet / Neutrophil ratio (PNR) was highly significant higher in NAFLD with diabetic patient than other two groups.
5. There was significant positive correlations between MPV and Weight, AST, ALT, Hb, INR and NAFLD fibrosis score.
6. ROC curve analysis showed that, at the cutoff 8.45 fl and AUC 71.4% the MPV can predict the NAFLD with specificity of 63%, sensitivity of 70 %.
7. ROC curve analysis for the prediction of diabetes using the MPV showed AUC 64%. Specificity of 57%, sensitivity of 70 % at the cutoff 8.45 fl.
8. Univariate analysis showed that NAFLD had a correlation with platelet count, neutrophils, lymphocytes, Hb, AST, ALT, MPV, weight, age, liver span and RBS.
9. Mulvariate analysis showed that NAFLD had correlation with platelet count, Hb, MPV and RB