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العنوان
Comparison between the Efficacy of
Intense Pulsed Light (IPL) versus
Photodynamic Therapy with Methylene
Blue in the Treatment of Nail Psoriasis /
المؤلف
Dakhli, Azzahra Omar.
هيئة الاعداد
مشرف / Azzahra Omar Dakhli
مشرف / Maha Adel Shaheen
مشرف / Samah Ibrahim Hassen
مناقش / Samah Ibrahim Hassen
تاريخ النشر
2019.
عدد الصفحات
112p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الأمراض الجلدية
تاريخ الإجازة
1/1/2019
مكان الإجازة
جامعة عين شمس - كلية الطب - الامراض الجلدية
الفهرس
Only 14 pages are availabe for public view

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Abstract

SUMMARY
ail psoriasis affects up to 50% of psoriatic patients with an
estimated lifetime incidence of 80% to 90%. Conversely,
up to 5% of patients have isolated nail psoriasis without skin
manifestations.
The lesions in nail psoriasis can arise from the nail
matrix (pitting, leukonychia, trachyonychia, Beau’s lines, red
spots in lunula and nail plate crumbling) and/or nail bed
(subungual hyperkeratosis, onycholysis, splinter hemorrhage,
and salmon patches). Nail psoriasis leads to a significant
cosmetic handicap and impairment in the quality of life.
The Nail Psoriasis Severity Index (NAPSI) is a numeric,
reproducible, objective, simple tool for clinical evaluation of
nail psoriasis.
Intense pulsed light (IPL) is a device that emits highintensity,
polychromatic (between 400 and 1200 nm), noncoherent
and non-collimated light. This allows to treat skin
vascular disorders such as vascular tumors and telangiectasia.
IPL has been used in the treatment of nail psoriasis due to the
vascular nature of the disease. The energy is captured by the
hemoglobin which leads to the destruction of the blood vessels.
Methylene blue (MB) is a widely known histological dye
that has been used to stain living organisms. It’s a hydrophilic
PS, with low molecular weight and positive charge. It belongs
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Summary 
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to the phenothiazinium class of compounds. The characteristic
color of MB is caused by the strong absorption band in the
550–700 nm regions. It is well known to generate singlet
oxygen, and the mitochondrial localization of this drug induce
cell death by apoptosis during photodynamic therapy (PDT).
Photodynamic therapy (PDT) is modern, safe, and noninvasive
form of therapy that has been successfully used in
dermatology.
In our study, we aimed to evaluate and compare the
efficacy of IPL and methylene blue assisted photodynamic
therapy for the treatment of nail psoriasis.
Twenty patients (15 males and 5 females) with different
degrees of nail psoriasis, were randomly selected from the
outpatient clinic of Dermatology, Venereology and Andrology,
Ain Shams University. Their age ranged from 24 to 71 years.
Each patient was subjected to a detailed history taking
and full examination. An informed consent was obtained after
explaining the aim of our study. Each patient had one session of
MB-PDT every two weeks, for 3 months, applied to the
affected nails of the right hand, and one session of IPL every
two weeks, for 3 months, applied to the affected nails of the left
hand. Two passes were performed. The hand piece was placed
adjacent to the surface of the nail covering the proximal and
lateral nail folds