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العنوان
Generation of Cholinergic Neurons from Human Olfactory Bulb Neural Stem Cells Using BMP9 Treatment /
الناشر
Asmaa Ahmed Abdou Moeit,
المؤلف
.Moeit, Asmaa Ahmed Abdou
هيئة الاعداد
باحث / Asmaa Ahmed Abdou Moeit
مشرف / Camelia A.Abdel Malak
مشرف / Hany El-Sayed Marei
مشرف / Mohammad Mostafa Omran
الموضوع
Cholinergic Neurons.
تاريخ النشر
2017.
عدد الصفحات
78 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
Biochemistry
تاريخ الإجازة
29/10/2017
مكان الإجازة
جامعة دمياط - كلية العلوم - الكيمياء
الفهرس
Only 14 pages are availabe for public view

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Abstract

Alzheimer’s disease (AD) as a chronic neurodegenerative disease, is characterized by early loss of specific cholinergic neurons in the basal forebrain (BFCBs). Looking for a suitable source for regeneration of these damaged BFCNs is the current scope for several researchers to restrict the progression of AD. Although, the diffusible ligands, SHH, FGF8, BMP9, and NGF have been successfully used to differentiate cholinergic neurons from human embryonic stem cells in vitro, but the potential of these factors to induce OBNSCs differentiation into cholinergic neurons has not been evaluated yet.
Therefore, this study aim to generate cholinergic neurons with basal forebrain fat (BFCNs) from hOBNSCs using diffusible ligands and to study the gene expression profile for the key genes involved in this differentiation.