الفهرس 
Review of LiteratureOnly 14 pages are availabe for public view
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Abstract
This study on Aspergillus flavus isolated from keratitis patients and from soil; suggests that AFB1 production occurs significantly and more frequently in clinical strains than it does in environmental strains. This observation has therapeutic applications, since it may be necessary to treat keratitis patients with molecules or substance extracted from natural, local, valuable and cheep origin such as the tested probiotics that suppress the growth of opportunistic fungi and it is clear that its medicinal value is comparable to the present day antibiotics. Because of the advantages of its antifungal activity; probiotics appears to have economic, clinical and public health importance, efficacy in inhibiting AFB1 production, easily preparation, low cost and availability as natural substance; these are a novel antifungal compounds which are identified and their chemical structure was elucidated from their IR and mass spectra; these compounds were dihydroindole derivative extracted from Lactobacillus bulgaricus and 2,6-dibutyl-9-arylacridine extracted from Saccharomyces cerevisiae. Also this study revealed that butanol is the proper solvent in the antifungal extraction from both S. cerevisiae and L. bulgaricus. This study showed the availability of using dihydroindole derivative and 2,6-dibutyl-9-arylacridine as antifungal antibiotics against Aspergillus flavus and A. parasiticus causing ocular ulcers. Moreover they found to have an efficacy in inhibiting their aflatoxin toxicity.