الفهرس 
Autism Spectrum Disorder (ASD)Only 14 pages are availabe for public view
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Abstract
Autism is a complex developmental condition that typically manifests in the first two years of life. The Centers for Disease Control and Prevention (2015) reported prevalence 1 in 45 US children. . In Egypt 23.8% of studied toddlers in enrolled Primary Health Care Units were suspected to have ASD with a male: female ratio of 3:1. Numerous studies of autistic individuals have revealed evidence of cerebral hypoperfusion , neuroinflammation , gastrointestinal inflammation, immune dysregulation, oxidative stress, relative mitochondrial dysfunction, and neurotransmitter abnormalities .Treatment with HBOT has been shown to possess potent anti-inflammatory properties also has been reported to decrease the production of pro-inflammatory cytokines as well as increase counter-inflammatory levels . Some investigators speculated that HBOT may be useful in improving behavioral and physiological abnormalities found in some children with ASD
Meta-analysis is an epidemiological technique for amalgamating, summarizing and reviewing previous quantitative research, by using meta-analysis.
Evidence-based Practice can be defined as ”the conscientious, explicit and judicious use of current best evidence in making decisions about the care of [clients]”.
The aim of the present study is to provide the meta-analysis study of Egyptian studies regarding efficacy of HyperBaric Oxygen Therapy as adjuvant treatment for children with autism spectrum disorder and to establish Egyptian evidence based guidelines.
Methodology: According to guidelines outlined by the preferred reporting items for systematic review and meta-analysis (PRISMA) statement, the researcher made the research in Medline, Eulc, Epic and other databases which were published up to end of December 2018.
The researcher visited the libraries (central and digital) in the medical faculties and nursing faculties as well, nutritional institute in Cairo, national research center in Cairo. The visited universities were, Cairo, Ain Shams, Azhar, Banha, Zagazig, Tanta, Shibin El-Kom, Mansoura,and Alexandria Universities. The researcher collected data from theses of Msc., MD., PHD which focus HBOT in children with ASD.The researcher reviewed the International & Egyptian theses, papers, journals, in English and Arabic language, searching for the eligible studies published to the end of December 2018. Egyptian studies were 611 study as regard Autism & 84 study for HBOT , then 11 studies included both Autism and HBOT, 4 only studies were eligible compared to 14 international ones .Meta-analysis was done using MedCalc software ver. 12.7.7.0. The pool of 4 Egyptian studies involved a total sample of 140 children with ASD and 40 of them acted as control children.
Results: Mean age for all ASD children cited significantly in all four Egyptian studies with total number of 140 participants, The propotion of male participants in all four studies was significant with total number 110 male participants (P= 0.0315) .The usage of HBOT chamber of low pressure in two studies was near significant with total number of 90 participants, P= 0.0994 %). Among 60 participants in two of our study, there was no significant improvements related to number of HBOT sessions (P= 0.601). CARS test Pre- HBOT done for 60 participants in two studies was significant P=0.004 while CARS Post-HBOT for same two studies was insignificant P=0.86 .Two of our Egyptian studies were analyzed with total number of 46 participants having ASD & receiving risperidone. (P= 0.216), and there was no significant improvement with HBOT on meta-analysis basis. Conclusion: This Meta-analysis study had very few number of Egyptian studies with small number of participants .There was insufficient evidence that HBOT improves health outcomes for autism. Its recommended for further randomized controlled trials as well as Sham controlled studies are needed with different pressures of HBOT.